Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM) Universitat Politècnica de València, Universitat de València. Camino de Vera, s/n 46022, Valencia, Spain.
CIBER de Bioingeniería, Biomateriales y Nanomedicina, Instituto de Salud Carlos III, 28029 Madrid, Spain.
Chem Rev. 2022 Aug 24;122(16):13636-13708. doi: 10.1021/acs.chemrev.2c00198. Epub 2022 Jul 22.
Cage compounds offer unique binding pockets similar to enzyme-binding sites, which can be customized in terms of size, shape, and functional groups to point toward the cavity and many other parameters. Different synthetic strategies have been developed to create a toolkit of methods that allow preparing tailor-made organic cages for a number of distinct applications, such as gas separation, molecular recognition, molecular encapsulation, hosts for catalysis, etc. These examples show the versatility and high selectivity that can be achieved using cages, which is impossible by employing other molecular systems. This review explores the progress made in the field of fully organic molecular cages and containers by focusing on the properties of the cavity and their application to encapsulate guests.
笼状化合物提供了类似酶结合位点的独特结合口袋，可以根据大小、形状和官能团进行定制，以指向空腔和许多其他参数。已经开发了不同的合成策略来创建一套方法工具，用于为许多不同的应用制备定制的有机笼，例如气体分离、分子识别、分子包封、催化宿主等。这些例子展示了使用笼状化合物可以实现的多功能性和高选择性，这是使用其他分子系统无法实现的。本文综述了完全有机分子笼和容器领域的进展，重点介绍了空腔的性质及其在包封客体方面的应用。
