Department of Otolaryngology, Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina.
University of Central Florida College of Medicine, Orlando, Florida.
Dermatol Surg. 2021 Jan 1;47(1):104-110. doi: 10.1097/DSS.0000000000002660.
Sebaceous carcinoma (SC) of the eyelid is a rare, aggressive malignancy associated with high rates of recurrence, metastasis, and tumor-related mortality.
Provide a collective analysis of clinical presentations, management techniques, and outcomes, and compare outcomes of common treatment methods.
Observational studies reporting management and outcomes of SC of the eyelid were included. Patient and clinical data were extracted, and meta-analysis of proportions was performed.
One thousand three hundred thirty-three subjects were included with a mean age of 65.2 years and 803 (60.2%) women. Of 647 initial diagnoses reported, 277 (42.8%) were correct, and the mean diagnostic delay was 14.7 months (range 8.5-34.8). The tumor location was reported in 1,246 subjects and involved the upper eyelid in 780 (62.6%), lower eyelid in 409 (32.8%), and 57 (4.8%) involved both. Overall rates of recurrence, metastasis, and tumor-related mortality were 15.9%, 12.1%, and 6.2%, respectively. There were no statistically significant differences in wide local excision (WLE) versus Mohs micrographic surgery (MMS) outcomes.
Sebaceous carcinoma of the eyelid is more common in women, on the upper eyelid, and is frequently misdiagnosed initially. Rate of recurrence, metastasis, and tumor-related mortality were similar in subjects managed with WLE versus MMS.
眼睑的皮脂癌（SC）是一种罕见的、侵袭性的恶性肿瘤，其复发率、转移率和肿瘤相关死亡率均较高。
对眼睑皮脂癌的临床表现、治疗方法和结局进行综合分析，并比较常见治疗方法的结局。
纳入了报道眼睑皮脂癌的管理和结局的观察性研究。提取患者和临床数据，并进行了比例的荟萃分析。
共纳入 1333 例患者，平均年龄为 65.2 岁，803 例（60.2%）为女性。在报告的 647 例初始诊断中，正确的有 277 例（42.8%），平均诊断延迟时间为 14.7 个月（范围 8.5-34.8）。1246 例报告了肿瘤位置，780 例（62.6%）累及上眼睑，409 例（32.8%）累及下眼睑，57 例（4.8%）累及上下眼睑。总的复发率、转移率和肿瘤相关死亡率分别为 15.9%、12.1%和 6.2%。广泛局部切除（WLE）与 Mohs 显微外科手术（MMS）的结局无统计学差异。
眼睑皮脂癌在女性中更为常见，多发生在上眼睑，且最初常被误诊。WLE 与 MMS 治疗的患者复发率、转移率和肿瘤相关死亡率相似。
