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使用多功能锅产生的湿热对受严重急性呼吸综合征冠状病毒2(SARS-CoV-2)污染的N95过滤式面罩呼吸器(FFR)进行消毒。

Decontamination of SARS-CoV-2 contaminated N95 filtering facepiece respirators (FFRs) with moist heat generated by a multicooker.

作者信息

Choi Y W, Richardson A W, Sunderman M, Mladineo M J, Keyes P H, Hofacre K C, Middleton J K

机构信息

Battelle Memorial Institute, Columbus, OH, USA.

出版信息

Lett Appl Microbiol. 2021 Apr;72(4):366-374. doi: 10.1111/lam.13443. Epub 2020 Dec 31.

Abstract

Decontamination of N95 filtering facepiece respirators (FFRs) is a crisis capacity strategy allowed when there are known shortages of FFRs. The application of moist heat is one decontamination method that has shown promise and is the approach approved in the Steris Steam Emergency Use Authorization (EUA). This effort examines the use of multicookers to apply moist heat, as they are available in retail stores and more affordable than methods requiring more sophisticated equipment. Four of five multicooker models examined met the acceptance criteria for the test and one model was selected for inactivation testing. Tests were performed on four different FFR models with SARS-CoV-2 suspended in culture media, simulated saliva or simulated lung fluid. Moist heat treatment reduced recoverable titres of SARS-CoV-2 virus to levels below the limit of detection in all tests. Furthermore, these four FFR models showed no loss in collection efficiency, inhalation resistance or visual damage after up to 10 decontamination cycles. Two (2) FFR models showed a slight change in strap elasticity (<9%). These data show that moist heat treatment using a multicooker is a viable option for FFR decontamination in a crisis capacity strategy.

摘要

在已知N95过滤式面罩呼吸器(FFR)短缺时,对其进行消毒是一种应急能力策略。湿热应用是一种已显示出前景的消毒方法,也是斯特里消毒蒸汽紧急使用授权(EUA)中批准的方法。本研究考察了使用多用途锅进行湿热处理的情况,因为多用途锅在零售店有售且比需要更复杂设备的方法更经济实惠。所考察的五种多用途锅型号中有四种符合测试的验收标准,并选择了一种型号进行灭活测试。对四种不同的FFR型号进行了测试,病毒悬液为培养基、模拟唾液或模拟肺液中的严重急性呼吸综合征冠状病毒2(SARS-CoV-2)。在所有测试中,湿热处理均将SARS-CoV-2病毒的可回收滴度降低至检测限以下水平。此外,这四种FFR型号在多达10次消毒循环后,收集效率、吸气阻力或外观均未受损。两种FFR型号的绑带弹性略有变化(<9%)。这些数据表明,在应急能力策略中,使用多用途锅进行湿热处理是FFR消毒的一种可行选择。

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