Phillip Frost Department of Dermatology, University of Miami, Miami, FL, USA.
San Gallicano Dermatological Institute, Rome, Italy.
J Cosmet Dermatol. 2021 Aug;20(8):2527-2530. doi: 10.1111/jocd.13893. Epub 2020 Dec 21.
Treatment of unwanted body hair is a challenging area in cosmetic dermatology. Topical soy isoflavones and derivatives or eflornithine have been utilized in dermatocosmetology for their estrogenic and antiandrogenic activity.
To evaluate the efficacy of a formulation containing capryloyl glycine 4% in decreasing hair growth on the forearms after topical application for 120 days vs placebo.
A total of 69 female patients entered the study (age 37 ± 6). Hair growth was quantified using TrichoScan software on both forearms at 20-fold magnification (analyzed area 0.651 cm2). Hair density (number of hairs/cm ), density vellus hair, density terminal hair, and median length of hairs were evaluated. The data were analyzed using ANOVA for repeated measures to evaluate changes during the treatment (T0, T60, and T120) and Student's t test (placebo vs active).
There was a significant decrease on hair density, median, and terminal hair at the end of the treatment in the active-treated site (P < .001) as measured by TrichoScan software. Direct comparison between active and placebo-treated sites showed no significant differences at T0, but highly significant differences at T120 (P < .001).
The study shows that a cosmetic formulation based on capryloyl glycine 4% is highly effective in reducing several parameters related to hair growth and hair thickness vs placebo, thus showing efficacy in the treatment of hypertrichosis.
治疗多余的体毛是美容皮肤科的一个具有挑战性的领域。局部大豆异黄酮及其衍生物或依氟鸟氨酸因其雌激素和抗雄激素活性而在皮肤美容学中得到应用。
评估一种含有 4%辛酸甘氨酸的制剂在外用 120 天后减少前臂毛发生长的疗效，与安慰剂相比。
共有 69 名女性患者进入研究（年龄 37±6）。使用 TrichoScan 软件在 20 倍放大倍数下评估两个前臂的毛发生长情况（分析面积为 0.651 cm2）。评估毛发密度（每厘米毛发数）、绒毛密度、终毛密度和毛发中位数长度。使用重复测量方差分析评估治疗期间（T0、T60 和 T120）的变化，并使用学生 t 检验（安慰剂与活性）评估活性与安慰剂治疗部位之间的差异。
使用 TrichoScan 软件测量，在治疗结束时，活性治疗部位的毛发密度、中位数和终毛均显著下降（P<0.001）。活性治疗部位与安慰剂治疗部位之间的直接比较在 T0 时无显著差异，但在 T120 时差异非常显著（P<0.001）。
该研究表明，一种基于 4%辛酸甘氨酸的化妆品配方在减少与毛发生长和毛发厚度相关的几个参数方面非常有效，与安慰剂相比，显示出治疗多毛症的疗效。
