Cell Sheet Tissue Engineering Center (CSTEC), Department of Pharmaceutics and Pharmaceutical Chemistry, Health Sciences, University of Utah, 30 South 2000 East, Salt Lake City, UT 84112, USA.
Cell Sheet Tissue Engineering Center (CSTEC), Department of Pharmaceutics and Pharmaceutical Chemistry, Health Sciences, University of Utah, 30 South 2000 East, Salt Lake City, UT 84112, USA; Department of Biomedical Engineering, University of Utah, 36 South, Wasatch Drive, Salt Lake City, UT 84112, USA.
J Control Release. 2021 Feb 10;330:696-704. doi: 10.1016/j.jconrel.2020.12.028. Epub 2020 Dec 19.
The evolution of drug discovery exploded in the early 20th century with the advent of critical scientific advancements in organic chemistry, chemical analysis, and purification. Early drug generations focused largely on symptom control and pain management, effective targets for small-molecule drugs. Recently, the attention in drug discovery has shifted to pursuit of radical cures. Cell therapy presents the ideal attributes of a promising new drug, targeting specific tissues based on chemotactic cues and modulating secretion of instructive regenerative molecules in response to dynamic signaling from disease environments. To actuate the therapeutic potential of cell therapy toward worldwide clinical use, cell delivery methods that can effectively localize and engraft mesenchymal stem cells (MSCs) with high disease-site fidelity and enable dynamic MSC bioactive function are paramount. In this review, we discuss the evolution of cell therapies with a focus on stem cell advantages, as well as the limitations to these therapies. This review aims to introduce cell sheet technology as a breakthrough cell therapy with demonstrated therapeutic success across indications for heart, liver, and kidney tissue regeneration. Opportunities and anticipated clinical impacts of cell sheet technology using MSCs are discussed.
药物发现的发展在 20 世纪初随着有机化学、化学分析和纯化方面的重大科学进步而爆炸式增长。早期的药物主要集中在控制症状和疼痛管理上，这是小分子药物的有效靶点。最近，药物发现的重点已经转向寻求根治方法。细胞疗法具有有前途的新药的理想特性，它基于趋化性信号来靶向特定组织，并响应疾病环境中的动态信号来调节有指导作用的再生分子的分泌。为了将细胞疗法的治疗潜力推向全球临床应用，能够有效定位和植入间充质干细胞（MSCs）并具有高疾病部位保真度的细胞输送方法，以及能够实现 MSC 生物活性功能的动态细胞输送方法至关重要。在这篇综述中，我们讨论了细胞疗法的发展，重点介绍了干细胞的优势，以及这些疗法的局限性。本篇综述旨在介绍细胞片技术，该技术已被证明在心脏、肝脏和肾脏组织再生的各种适应症中具有治疗成功，并讨论了使用 MSCs 的细胞片技术的机会和预期的临床影响。
