Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China.
Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China.
J Affect Disord. 2021 Feb 15;281:351-357. doi: 10.1016/j.jad.2020.12.028. Epub 2020 Dec 11.
The direct relationship between inflammation and depression in patients with diabetes is still unclear. We examined the association between serum C-reactive protein (CRP) levels and the high prevalence of depression in populations (aged ≥49 years) with and without type 2 diabetes.
Cross-sectional and longitudinal data from 3895 participants obtained from The Irish Longitudinal Study on Ageing (TILDA) were analyzed to determine the association between serum CRP levels and depression, accounting for relevant confounding factors.
Multivariable analyses showed a positive association between serum CRP and depression score, independent of age and gender, BMI, marital status, education, smoking status, alcohol drinking status, systolic BP, diastolic BP, physical activity, self-reported CVDs and laboratory measurements in subjects with diabetes mellitus (coefficient = 0.179, P<0.001) but not in subjects without diabetes mellitus (coefficient = 0.011, P = 0.495). Higher serum CRP levels were associated with an increased risk of depressive symptoms in subjects with diabetes mellitus (OR = 1.301, 95% CI 1.012-1.799, P = 0.011) but not in subjects without diabetes mellitus (OR = 1.004, 95% CI 0.992-1.013, P = 0.344) after adjusting for these same confounding factors. After a follow-up of 4 years, higher serum CRP levels were significantly associated with a higher possibility of depression events in subjects with diabetes mellitus.
Time-varying confounding factors may interfere with our results.
We observed a significant positive association between serum CRP levels and the prevalence of depressive symptoms in a middle-aged and elderly population with diabetes after adjustment for a range of lifestyle factors.
炎症与糖尿病患者抑郁之间的直接关系仍不清楚。我们研究了血清 C 反应蛋白（CRP）水平与 2 型糖尿病和非 2 型糖尿病人群（年龄≥49 岁）中抑郁高发之间的关联。
分析了来自爱尔兰老龄化纵向研究（TILDA）的 3895 名参与者的横断面和纵向数据，以确定血清 CRP 水平与抑郁之间的关联，同时考虑了相关的混杂因素。
多变量分析显示，在患有糖尿病的受试者中，血清 CRP 与抑郁评分呈正相关，与年龄和性别、BMI、婚姻状况、教育程度、吸烟状况、饮酒状况、收缩压、舒张压、体力活动、自我报告的心血管疾病和实验室测量无关（系数=0.179，P<0.001），但在无糖尿病的受试者中则无关（系数=0.011，P=0.495）。较高的血清 CRP 水平与糖尿病患者抑郁症状的风险增加相关（OR=1.301，95%CI 1.012-1.799，P=0.011），但在无糖尿病的受试者中则无此关联（OR=1.004，95%CI 0.992-1.013，P=0.344），同时调整了这些相同的混杂因素。在 4 年的随访后，较高的血清 CRP 水平与糖尿病患者发生抑郁事件的可能性增加显著相关。
时变混杂因素可能会干扰我们的结果。
我们观察到，在调整了一系列生活方式因素后，血清 CRP 水平与中年和老年糖尿病患者抑郁症状的患病率之间存在显著的正相关关系。
