Gislason T, Lindholm C E, Almqvist M, Birring E, Boman G, Eriksson G, Larsson S G, Lidell C, Svanholm H
Department of Lung Medicine, Uppsala Sweden University.
Arch Otolaryngol Head Neck Surg. 1988 Jan;114(1):45-51. doi: 10.1001/archotol.1988.01860130049013.
A prospective study of 34 consecutive patients with the sleep apnea syndrome was undertaken to evaluate the effectiveness and complications of, and predictors of, results in a conservative type of uvulopalatopharyngoplasty (UPPP). At six months, 65% of the patients had a 50% or greater reduction in the number of apneas and hypopneas per hour (responders). The responders to UPPP were less severely affected preoperatively regarding apneas and hypopneas, the mean number of which (+/- SD) were 32.7 +/- 20.8 compared with 64.6 +/- 26.0. They also had a lower body mass index before UPPP (31.3 +/- 4.1 vs 36.0 +/- 7.0 kg/m2). Preoperative computed tomography and cephalometry indicated that the nonresponders had narrower upper airways. It is concluded that UPPP is the treatment of choice for mild to moderate sleep apnea syndrome, but not for severely affected, heavily overweight patients with an increased tongue width.
对34例连续性睡眠呼吸暂停综合征患者进行了一项前瞻性研究，以评估保守型悬雍垂腭咽成形术（UPPP）的有效性、并发症及疗效预测因素。六个月时，65%的患者每小时呼吸暂停和低通气次数减少50%或更多（有反应者）。UPPP的有反应者术前呼吸暂停和低通气的严重程度较轻，其平均次数（±标准差）为32.7±20.8，而无反应者为64.6±26.0。他们在UPPP术前的体重指数也较低（31.3±4.1 vs 36.0±7.0 kg/m²）。术前计算机断层扫描和头影测量表明，无反应者的上气道较窄。结论是，UPPP是轻度至中度睡眠呼吸暂停综合征的首选治疗方法，但不适用于病情严重、严重超重且舌体增宽的患者。
