Fujita S, Conway W A, Zorick F J, Sicklesteel J M, Roehrs T A, Wittig R M, Roth T
Laryngoscope. 1985 Jan;95(1):70-4. doi: 10.1288/00005537-198501000-00017.
A new surgical procedure to treat obstructive sleep apnea by uvulopalatopharyngoplasty (UPPP) was evaluated in 66 patients, 63 men and 3 women, with objectively documented sleep apnea syndrome. Removal of redundant tissue in the oropharynx (UPPP) significantly improved excessive daytime sleepiness, reduced by half the frequency of apneas and hypoxia occurring during sleep, and improved the quality of sleep. Closer analysis indicated that all 66 patients did not benefit to the same degree. Among patients classified as responders, the frequency of apnea was reduced to a level seen in healthy adults of the same age, measures of sleep approached normal, and excessive daytime sleepiness was eliminated. In nonresponders, frequency of apnea and consequent disruption of sleep was not reduced, but nocturnal hypoxia was improved.
通过悬雍垂腭咽成形术（UPPP）治疗阻塞性睡眠呼吸暂停的一种新手术方法在66例患者中进行了评估，其中63例男性和3例女性，均有客观记录的睡眠呼吸暂停综合征。切除口咽多余组织（UPPP）显著改善了日间过度嗜睡，将睡眠期间发生的呼吸暂停和低氧血症频率降低了一半，并改善了睡眠质量。进一步分析表明，并非所有66例患者都获得了相同程度的益处。在分类为有反应者的患者中，呼吸暂停频率降至同年龄健康成年人的水平，睡眠指标接近正常，日间过度嗜睡也消除了。在无反应者中，呼吸暂停频率及随之而来的睡眠中断并未降低，但夜间低氧血症有所改善。
