Department of Medicine, Division of Cardiovascular Medicine, SUNY Downstate Health Sciences University, Brooklyn, New York, USA.
Department of Urology, SUNY Downstate Health Sciences University, Brooklyn, New York, USA.
Neurourol Urodyn. 2021 Jan;40(1):509-514. doi: 10.1002/nau.24590. Epub 2020 Dec 21.
Nocturia has been increasingly recognized as a potential manifestation of cardiovascular disease. However, the relationship between nocturia and electrocardiographic (ECG) abnormalities has not been studied. This study aims to characterize the diagnostic utility of nocturia in identifying left ventricular hypertrophy (LVH), left atrial enlargement (LAE), and prolonged QTc on ECG.
Retrospective analysis of nocturnal voiding frequency and contemporaneous ECG data from consecutive patients evaluated at a university-based outpatient cardiology clinic. Three sets of three incremental binary multiple logistic regression models controlling for (1) age, (2) sex and race, and (3) body mass index, hypertension, diabetes mellitus, and diuretic utilization were performed to determine whether nocturia was predictive of LVH, LAE, and prolonged QTc.
Included patients (n = 143, 77.6% nocturia) were predominantly African-American (89.5%), female (74.1%), and obese (61.5%), of whom 44.1%, 41.3%, and 27.3% had LVH, LAE, and prolonged QTc, respectively. Older age, African-American race, obesity, hypertension, diuretic use, LVH, and LAE were significantly associated with nocturia on univariate analysis. No significant differences were observed in the strength of associations between nocturia and LVH, LAE, or QTc prolongation based on age. Nocturia independently predicted LVH in Models I-III (odds ratios [ORs], 2.99-3.20; relative risks [RRs], 1.18 for all, p ≤ .046) and LAE in Models I-III (ORs, 4.24-4.72; RRs, 1.21 for all, p ≤ .015). No significant associations were observed between nocturia and prolonged QTc.
Nocturia may be a risk marker for underlying structural cardiac abnormalities.
夜尿症已被越来越多地认为是心血管疾病的潜在表现。然而，夜尿症与心电图（ECG）异常之间的关系尚未得到研究。本研究旨在描述夜尿症在识别左心室肥厚（LVH）、左心房扩大（LAE）和心电图上的 QTc 延长方面的诊断效用。
对在一所大学门诊心脏病诊所评估的连续患者的夜间排尿频率和同期心电图数据进行回顾性分析。进行了三套三个递增的二进制多重逻辑回归模型，控制了（1）年龄，（2）性别和种族，以及（3）体重指数、高血压、糖尿病和利尿剂的使用，以确定夜尿症是否可预测 LVH、LAE 和 QTc 延长。
纳入的患者（n=143，77.6%有夜尿症）主要为非裔美国人（89.5%）、女性（74.1%）和肥胖（61.5%），其中 44.1%、41.3%和 27.3%分别有 LVH、LAE 和 QTc 延长。年龄较大、非裔美国人、肥胖、高血压、利尿剂使用、LVH 和 LAE 在单变量分析中与夜尿症显著相关。基于年龄，在夜尿症与 LVH、LAE 或 QTc 延长之间的关联强度上没有观察到显著差异。夜尿症独立预测了模型 I-III 中的 LVH（比值比[OR]，2.99-3.20；相对风险[RR]，所有的 1.18，p≤.046）和模型 I-III 中的 LAE（OR，4.24-4.72；RR，所有的 1.21，p≤.015）。夜尿症与 QTc 延长之间没有显著关联。
夜尿症可能是潜在结构性心脏异常的风险标志物。
