Kirin Central Research Institute, Kirin Holdings Company Ltd., 1-13-5, Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan.
Division of Pharmacology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
Int J Mol Sci. 2020 Dec 17;21(24):9612. doi: 10.3390/ijms21249612.
As daily lifestyle is closely associated with mental illnesses, diet-based preventive approaches are receiving attention. Supplementation with hop bitter acids such as iso-α-acids (IAA) and mature hop bitter acids (MHBA) improves mood states in healthy older adults. However, the underlying mechanism remains unknown. Since acute oral consumption with IAA increases dopamine levels in hippocampus and improves memory impairment via vagal nerve activation, here we investigated the effects of chronic administration of hop bitter acids on the dopaminergic activity associated with emotional disturbance in a mouse model of repeated social defeat stress (R-SDS). Chronic administration of IAA and MHBA significantly increased dopaminergic activity based on the dopamine metabolite to dopamine ratio in the hippocampus and medial prefrontal cortex following R-SDS. Hippocampal dopaminergic activity was inversely correlated with the level of R-SDS-induced social avoidance with or without IAA administration. Therefore, chronic treatment with hop bitter acids enhances stress resilience-related hippocampal dopaminergic activity.
由于日常生活方式与精神疾病密切相关，基于饮食的预防方法受到关注。补充酒花苦味酸，如异α-酸（IAA）和成熟酒花苦味酸（MHBA），可改善健康老年人的情绪状态。然而，其潜在机制尚不清楚。由于急性口服 IAA 可增加海马中的多巴胺水平，并通过迷走神经激活改善记忆障碍，因此我们在此研究了慢性给予酒花苦味酸对反复社交挫败应激（R-SDS）小鼠模型中与情绪障碍相关的多巴胺能活动的影响。慢性给予 IAA 和 MHBA 可显著增加 R-SDS 后海马和内侧前额叶皮质中多巴胺代谢物与多巴胺比值的多巴胺能活性。海马中的多巴胺能活性与 R-SDS 诱导的社会回避水平呈负相关，无论是否给予 IAA。因此，慢性给予酒花苦味酸可增强与应激弹性相关的海马多巴胺能活性。
