Service d'ophtalmologie, Sorbonne université, hôpital Tenon, AP-HP, 4, rue de la Chine, 75020 Paris, France.
Service d'ophtalmologie, hôpital Tenon, AP-HP, Paris, France; Service d'ophtalmologie, faculté de médecine, CHU Gabriel Montpied, université de Clermont-Ferrand, France.
J Fr Ophtalmol. 2021 Jan;44(1):e1-e12. doi: 10.1016/j.jfo.2020.11.001. Epub 2020 Dec 23.
To localize the brain structures involved in blepharospasm.
This is a retrospective consecutive series of brain MRI's of patients with secondary blepharospasm whose immediate past medical history included cerebrovascular accident or head trauma.
Six patients, including 4 with CVA with ischemic or hemorrhagic lesions of the thalamus and caudate nuclei and 2 with head trauma with contusive sequellae to the tectal plate and frontal cortical and cerebellar atrophy.
According to the literature, brain lesions associated with blepharospasm involve mainly the thalamus, head of the caudate nucleus, corpus striatum, globus pallidus, internal capsule, cerebral cortex and cerebellum. This study demonstrates that blepharospasm is associated with a lesion of a complex neural network - cortex-thalamus-globus pallidus-cortex - and does not correspond to a single, unique lesion. This network is connected with ascending and descending sensory-motor pathways and motor nuclei.
定位与眼睑痉挛相关的脑结构。
这是一系列回顾性连续的脑 MRI 研究，研究对象为患有继发性眼睑痉挛的患者，他们的近期病史包括脑血管意外或头部外伤。
共有 6 名患者，其中 4 名患者 CVA 合并丘脑和尾状核的缺血性或出血性病变，2 名患者头部外伤合并脑顶盖和额皮质及小脑萎缩的挫伤后遗症。
根据文献，与眼睑痉挛相关的脑损伤主要涉及丘脑、尾状核头部、纹状体、苍白球、内囊、大脑皮质和小脑。本研究表明，眼睑痉挛与复杂神经网络的损伤有关 - 皮质-丘脑-苍白球-皮质 - 而不是单一的、独特的损伤。该网络与感觉运动上行和下行通路以及运动核相连。
