Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Department of Cardiology, Ren Ji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
J Cosmet Dermatol. 2021 Sep;20(9):2715-2722. doi: 10.1111/jocd.13884. Epub 2020 Dec 21.
Rosacea and cardiovascular diseases (CVD) are chronic inflammatory disorders. While CVD is the leading cause of mortality globally, increasing evidence indicates that CVD prevalence could be higher among patients with rosacea.
This review aimed to determine the association between the prevalence of CVD and rosacea.
PATIENTS/METHODS: A systematic review of observational studies with controls available in MEDLINE, EMBASE, PubMed, Cochrane, and Web of Science databases was conducted. We performed a pooled meta-analysis using random-effects weighting. Overall, 11 studies met the inclusion criteria, which indicated increased odds for at least one risk factor of CVD, including diabetes, high blood pressure, or dyslipidemia.
The pooled meta-analysis indicated an association of rosacea with higher odds of insulin resistance or diabetes (odds ratio [OR], 1.18; 95% confidence interval [CI], 0.97-1.45), high systolic blood pressure (OR, 1.96; 95% CI, 1.35-2.84), dyslipidemia (OR, 1.50; 95% CI, 1.19-1.88), and CVD (OR, 6.65; 95% CI, 2.80-15.76). No publication bias was detected. The effect of confounding factors due to overlapping symptoms and lack of individual-level data were limitations of this review.
Patients with rosacea have a high risk of CVD. However, further studies are warranted to confirm the association between rosacea and CVD.
酒渣鼻和心血管疾病（CVD）都是慢性炎症性疾病。虽然 CVD 是全球范围内导致死亡的主要原因，但越来越多的证据表明，酒渣鼻患者的 CVD 患病率可能更高。
本综述旨在确定 CVD 和酒渣鼻之间的患病率关联。
患者/方法：对 MEDLINE、EMBASE、PubMed、Cochrane 和 Web of Science 数据库中具有对照的观察性研究进行了系统回顾。我们使用随机效应加权进行了汇总荟萃分析。共有 11 项研究符合纳入标准，这些研究表明，至少有一种 CVD 风险因素（包括糖尿病、高血压或血脂异常）的患病风险增加。
汇总荟萃分析表明，酒渣鼻与胰岛素抵抗或糖尿病（比值比 [OR]，1.18；95%置信区间 [CI]，0.97-1.45）、收缩压升高（OR，1.96；95% CI，1.35-2.84）、血脂异常（OR，1.50；95% CI，1.19-1.88）和 CVD（OR，6.65；95% CI，2.80-15.76）的患病风险增加相关。未发现发表偏倚。由于重叠症状和缺乏个体水平数据导致的混杂因素的影响是本综述的局限性。
患有酒渣鼻的患者患 CVD 的风险较高。然而，需要进一步的研究来证实酒渣鼻与 CVD 之间的关联。
