Tsai Tsung-Yu, Chiang Ying-Yi, Huang Yu-Chen
Department of Dermatology, Wan Fang Hospital, Taipei Medical University, 111, Hsing-Long Road Sec. 3, Wenshan District, Taipei City 116, Taiwan.
Acta Derm Venereol. 2020 Oct 21;100(17):adv00300. doi: 10.2340/00015555-3668.
The association between rosacea and cardiovascular disease remains controversial. A systematic review and meta-analysis of the literature, from inception to 15 February 2020, was performed to compare cardiovascular risk and comorbidities in individuals with and without rosacea. Twelve studies, involving 40,752 patients with rosacea, were included. Compared with controls, patients with rosacea had higher systolic blood pressure (standardized mean difference (SMD) 0.293, 95% confidence interval (CI) 0.054-0.532), diastolic blood pressure (SMD 0.309, 95% CI 0.003-0.615), total cholesterol (SMD 1.147, 95% CI 0.309-1.984), low-density lipoprotein (SMD 0.792, 95% CI 0.174-1.409), C-reactive protein (SMD 0.26, 95% CI 0.099-0.421), greater epicardial fat thickness (SMD 1.945, 95% CI 1.595-2.296), and higher incidence of hypertension (odds ratio (OR) 1.204, 95% CI 1.097-1.332) and insulin resistance (OR 2.338, 95% CI 1.187-4.605). This study reveals that patients with rosacea are predisposed to increased subclinical cardiovascular risk.
酒渣鼻与心血管疾病之间的关联仍存在争议。我们进行了一项从文献起始至2020年2月15日的系统综述和荟萃分析，以比较患有和未患有酒渣鼻的个体的心血管风险及合并症。纳入了12项研究，涉及40752例酒渣鼻患者。与对照组相比，酒渣鼻患者的收缩压更高（标准化均数差（SMD）0.293，95%置信区间（CI）0.054 - 0.532）、舒张压更高（SMD 0.309，95% CI 0.003 - 0.615）、总胆固醇更高（SMD 1.147，95% CI 0.309 - 1.984）、低密度脂蛋白更高（SMD 0.792，95% CI 0.174 - 1.409）、C反应蛋白更高（SMD 0.26，95% CI 0.099 - 0.421）、心外膜脂肪厚度更大（SMD 1.945，95% CI 1.595 - 2.296），以及高血压发病率更高（比值比（OR）1.204，95% CI 1.097 - 1.332）和胰岛素抵抗发生率更高（OR 2.338，95% CI 1.187 - 4.605）。这项研究表明，酒渣鼻患者易出现亚临床心血管风险增加。
