Jun-Ping H U, Dan-Dan Cao, Bo-Wei J U, Jian-Hua Yang
School of Pharmacy, Xinjiang Medical University Urumqi 830011, China.
the First Affiliated Hospital of Xinjiang Medical University Urumqi 830000, China.
Zhongguo Zhong Yao Za Zhi. 2020 Oct;45(20):4896-4901. doi: 10.19540/j.cnki.cjcmm.20200706.304.
To investigate the transnasal absorption characteristics of Cistanche deserticola phenylethanol glycosides nanoemulsion and its influencing factors. With the use of the classic in vivo nasal circulation perfusion model in rats, the absorption rate constant was used as the index to compare the nasal absorption characteristics of C. deserticola phenylethanol glycosides nanoemulsion and its aqueous solution in different concentrations, and to explore the effects of pH value of the preparation and absorption accelerator Azone on the nasal absorption of C. deserticola phenylethanol glycosides nanoemulsion. The results showed that, as compared with the aqueous solution group, the absorption rate constant was significantly higher in C. deserticola phenylethanol glycosides nanoemulsion with the same concentration(P<0.05), and C. deserticola phenylethanol glycosides nanoemulsion was more easily absorbed by the nasal cavity of rats; with the increase of the concentration of C. deserticola phenylethanol glycosides, the transnasal absorption amount of nanoemulsion was also increased in a dose-dependent manner. When the pH value of nanoemulsion was 6.0 and the ratio of Azone was 2%, the absorption rate constant was highest and the effect of promoting infiltration was the best.
考察肉苁蓉苯乙醇苷纳米乳的鼻腔吸收特性及其影响因素。采用经典的大鼠体内鼻腔循环灌流模型，以吸收速率常数为指标，比较不同浓度肉苁蓉苯乙醇苷纳米乳及其水溶液的鼻腔吸收特性，探讨制剂pH值和吸收促进剂氮酮对肉苁蓉苯乙醇苷纳米乳鼻腔吸收的影响。结果表明，与水溶液组比较，相同浓度的肉苁蓉苯乙醇苷纳米乳吸收速率常数显著提高（P<0.05），肉苁蓉苯乙醇苷纳米乳更易被大鼠鼻腔吸收；随着肉苁蓉苯乙醇苷浓度增加，纳米乳的经鼻吸收量也呈剂量依赖性增加。纳米乳pH值为6.0、氮酮比例为2%时，吸收速率常数最高，促渗效果最佳。
