Sparnins V L, Mott A W, Barany G, Wattenberg L W
Nutr Cancer. 1986;8(3):211-5. doi: 10.1080/01635588609513895.
Allyl methyl trisulfide (AMT), a constituent of garlic oil, was studied for its effects on glutathione S-transferase (GST) activity and on benzo[a]pyrene (BP)-induced neoplasia of the forestomach and lungs of female A/J mice. AMT induced increased GST activity in the forestomach, small bowel mucosa, liver, and lung. The forestomach and small bowel mucosa responded to a single low dose of AMT (3.0 mumol) given by oral intubation, whereas liver and lung were less reactive. A dose schedule of two administrations of 15 mumol AMT given 48 hours apart gave close-to-maximum induction in all four tissues and was chosen for investigation of its inhibitory effects. With this dose schedule, AMT produced an inhibition of BP-induced neoplasia of the forestomach as shown by a greater than 70% reduction in the number of tumors found at the completion of the experiment. Inhibition of pulmonary neoplasia did not occur. AMT is a member of a new class of naturally occurring chemicals that have the capacity to inhibit chemical carcinogenesis.
烯丙基甲基三硫化物（AMT）是大蒜油的一种成分，研究了其对谷胱甘肽S-转移酶（GST）活性以及对苯并[a]芘（BP）诱导的雌性A/J小鼠前胃和肺部肿瘤形成的影响。AMT可诱导前胃、小肠黏膜、肝脏和肺中的GST活性增加。前胃和小肠黏膜对经口插管给予的单次低剂量AMT（3.0微摩尔）有反应，而肝脏和肺的反应性较低。每隔48小时给予两次15微摩尔AMT的给药方案在所有四个组织中产生了接近最大程度的诱导作用，并被选择用于研究其抑制作用。采用该给药方案时，AMT对BP诱导的前胃肿瘤形成产生了抑制作用，实验结束时发现的肿瘤数量减少了70%以上。对肺部肿瘤形成未产生抑制作用。AMT是一类新型天然存在的化学物质的成员，这类物质具有抑制化学致癌作用的能力。
