Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran.
Epigenomics. 2021 Jan;13(1):65-81. doi: 10.2217/epi-2020-0241. Epub 2020 Dec 22.
miRNAs, small noncoding RNAs with crucial diagnostic and prognostic capabilities, play essential therapeutic roles in different human diseases. These biomarkers are involved in several biological mechanisms and are responsible for the regulation of multiple genes expressions in cells. miRNA-based therapy has shown a very bright future in the case of clinical interventions. Melatonin, the main product of the pineal gland, is a multifunctional neurohormone with numerous therapeutic potentials in human diseases. Melatonin is able to regulate miRNAs in different pathologies such as malignant and nonmalignant diseases, which can be considered as a novel kind of targeted therapy. Herein, this review discusses possible therapeutic utility of melatonin for the regulation of miRNAs in various pathological conditions.
miRNAs 是具有重要诊断和预后能力的小非编码 RNA，在人类的多种疾病中发挥着重要的治疗作用。这些生物标志物参与了多个生物学机制，并负责调节细胞内多个基因的表达。基于 miRNA 的治疗在临床干预中显示出了非常光明的前景。褪黑素是松果腺的主要产物，是一种多功能神经激素，在人类疾病中有许多治疗潜力。褪黑素能够调节多种疾病中的 miRNAs，如恶性和非恶性疾病，这可以被认为是一种新型的靶向治疗。本文综述了褪黑素调节各种病理条件下 miRNAs 的可能治疗用途。
