Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Science, Tabriz, Iran.
Department of Clinical Biochemistry, Urmia University of Medical Sciences, Urmia, Iran.
Chem Biol Drug Des. 2021 Sep;98(3):323-340. doi: 10.1111/cbdd.13849. Epub 2021 Jul 16.
The melatonin hormone secreted by the pineal gland is involved in physiological functions such as growth and maturation, circadian cycles, and biological activities including antioxidants, anti-tumor, and anti-ischemia. Melatonin not only interacts with proteins but also has functional effects on regulatory RNAs such as long non-coding RNAs (lncRNAs) and microRNAs (miRNAs). In this study, we overview various physiological and pathological conditions affecting melatonin through lncRNA and miRNA. The information compiled herein will serve as a solid foundation to formulate ideas for future mechanistic studies on melatonin. It will also provide a chance to more clarify the emerging functions of the non-coding transcriptome.
松果体分泌的褪黑素激素参与生长和成熟、昼夜节律等生理功能，以及抗氧化、抗肿瘤、抗缺血等生物活性。褪黑素不仅与蛋白质相互作用，而且对长链非编码 RNA（lncRNA）和 microRNA（miRNA）等调节 RNA 具有功能作用。在这项研究中，我们综述了通过 lncRNA 和 miRNA 影响褪黑素的各种生理和病理条件。本文所汇集的信息将为制定未来褪黑素机制研究的思路提供坚实的基础，也将有机会更清楚地阐明非编码转录组的新兴功能。
