Jimenez R, Gullon J, Monte M J, Esteller A
Department of Physiology and Pharmacology, University of Salamanca, Spain.
Cornell Vet. 1988 Jan;78(1):99-104.
Biliary excretion rate of bilirubin and biliverdin from fasted and fed conscious rabbits has been investigated. The animals were cholecystectomized and fitted with a chronic surgical double recurrent choledoco-choledocal biliary fistula. The enterohepatic circulation of bile salts were maintained by bile administration. Mean bile flow, biliary concentrations and excretion rates of bilirubin and biliverdin remained constant during fasting conditions. After feeding bile flow and biliary output of biliverdin increased whereas that of bilirubin did not. The higher excretion rate of biliverdin after feeding could be explained by the low biliverdin reductase activity in this species and the stimulation of biliverdin formation by postprandial factors.
对禁食和喂食状态下清醒家兔胆红素和胆绿素的胆汁排泄率进行了研究。动物行胆囊切除术，并安装慢性外科双复发性胆总管-胆总管胆汁瘘。通过给予胆汁维持胆盐的肠肝循环。在禁食状态下，平均胆汁流量、胆红素和胆绿素的胆汁浓度及排泄率保持恒定。喂食后胆汁流量和胆绿素的胆汁排出量增加，而胆红素的排出量未增加。喂食后胆绿素排泄率较高可归因于该物种中胆绿素还原酶活性较低以及餐后因素对胆绿素形成的刺激。
