Vedal S, Welsh E V, Miller R R, Müller N L
Department of Medicine, University of British Columbia, Vancouver General Hospital, Canada.
Chest. 1988 Jan;93(1):215-7. doi: 10.1378/chest.93.1.215.
Noninvasive methods for diagnosis, assessing prognosis, and following response to treatment in idiopathic pulmonary fibrosis (IPF) have yet to prove their usefulness. We report a patient with desquamative interstitial pneumonia (DIP) in whom computed tomography (CT) suggested the diagnosis by the presence of patchy areas of haziness predominantly in a peripheral distribution. The chest x-ray and physical examinations, and the arterial blood gases showed normal findings after one month of treatment with corticosteroids, at which time the CT scan and lung volumes were still abnormal. At three months, lung volumes and the CT scan were normal. Hazy densities in a peripheral distribution on CT may indicate active IPF associated with a good prognosis.
用于特发性肺纤维化（IPF）诊断、评估预后及监测治疗反应的非侵入性方法尚未证明其有效性。我们报告一名患有脱屑性间质性肺炎（DIP）的患者，其计算机断层扫描（CT）显示主要在外周分布的斑片状模糊区域，提示了诊断。胸部X光检查、体格检查以及动脉血气分析显示，在使用皮质类固醇治疗一个月后结果正常，此时CT扫描和肺容积仍异常。三个月时，肺容积和CT扫描恢复正常。CT上外周分布的模糊密度可能提示与良好预后相关的活动性IPF。
