Department of Biomedical Engineering, University of Utah, 36 S. Wasatch Dr., Salt Lake City, UT 84112, USA.
Department of Biomedical Engineering, University of Utah, 36 S. Wasatch Dr., Salt Lake City, UT 84112, USA.
Adv Drug Deliv Rev. 2021 Feb;169:152-167. doi: 10.1016/j.addr.2020.12.009. Epub 2020 Dec 24.
Carbohydrates play essential structural and biochemical roles in all living organisms. Glycopolymers are attractive as well-defined biomimetic analogs to study carbohydrate-dependent processes, and are widely applicable biocompatible materials in their own right. Glycopolypeptides have shown great promise in this area since they are closer structural mimics of natural glycoproteins than other synthetic glycopolymers and can serve as carriers for biologically active carbohydrates. This review highlights advances in the area of design and synthesis of such materials, and their biomedical applications in therapeutic delivery, tissue engineering, and beyond.
碳水化合物在所有生物中都起着重要的结构和生化作用。糖聚合物是一种有吸引力的、定义明确的仿生模拟物，可以用来研究依赖碳水化合物的过程，而且本身就是广泛适用的生物相容性材料。糖多肽在这一领域具有很大的应用前景，因为它们比其他合成糖聚合物更接近天然糖蛋白的结构模拟物，并且可以作为生物活性碳水化合物的载体。这篇综述重点介绍了这类材料的设计和合成方面的进展，以及它们在治疗药物输送、组织工程等领域的生物医学应用。
