Ahlem Bchir, Manel Njima, Nouha Ben Abdeljalil, Seiffeddine Ben Hammouda, Khalifa Mighri, Leila Njim, Abdelfateh Zakhama
Department of Pathology, Fattouma Bourguiba University Hospital of Monastir, 5000, Tunisia; Faculty of Medecine, University of Monastir, 5000, Tunisia.
Faculty of Medecine, University of Monastir, 5000, Tunisia; Department of Head and Neck, Tahar Sfar University Hospital of Mahdia, 5100, Tunisia.
Int J Surg Case Rep. 2021 Jan;78:162-166. doi: 10.1016/j.ijscr.2020.12.014. Epub 2020 Dec 13.
Adenoid cystic carcinoma (ACC) is a rare tumor developed in minor salivary glands, the palate being the most common site.
Here, we report a case of a 58-year-old man with a 3-year-growing swelling in the right palate diagnosed with high grade transformation adenoid cystic carcinoma. The exam revealed a 4 cm large mass. A tumor resection with a radical neck dissection was performed.
High grade transformation in adenoid cystic carcinoma is recently described by Cheuk et al. in 1999. This transformation has more aggressive behavior than conventional solid ACC and has usually been associated with recurrences, early distant metastasis, and greater mortality.
The aim here is to highlight clinical, histopathological, therapeutic and prognostic aspects of high-grade transformation in ACC with literature review.
腺样囊性癌（ACC）是一种发生于小唾液腺的罕见肿瘤，腭部是最常见的发病部位。
在此，我们报告一例58岁男性患者，其右侧腭部肿物生长3年，诊断为高级别转化型腺样囊性癌。检查发现一个4厘米大的肿块。进行了肿瘤切除及根治性颈清扫术。
Cheuk等人于1999年首次描述了腺样囊性癌的高级别转化。这种转化比传统实性ACC具有更具侵袭性的行为，通常与复发、早期远处转移及更高的死亡率相关。
本文旨在通过文献复习强调腺样囊性癌高级别转化的临床、组织病理学、治疗及预后方面。
