Kostrzębska Agnieszka, Musiał Witold
Department of Physical Chemistry and Biophysics, Faculty of Pharmacy, Wroclaw Medical University, ul. Borowska 211A, 50-556 Wrocław, Poland.
Pharmaceutics. 2020 Dec 18;12(12):1228. doi: 10.3390/pharmaceutics12121228.
Alcoholamines are widely used as auxiliary substances in various topical preparations. Their impact on the components of skin sebum allows them to be used in preparations that cleanse the skin of sebum in hair follicles. We measured the effects of various concentrations of aqueous solutions of AMPD (2-amino-2-methyl-1,3-propanediol) on model skin sebum. The volume of reacted sebum was calculated using two methods: optical assessment of the interaction of alcoholamines with the components of model skin sebum and determination of the reacted volume of model skin sebum based on the measurements of changes in the pH of the AMPD solutions. Both methods showed that the most favorable AMPD concentration for model sebum penetration was approximately 1-2%. Lower values of alcoholamine caused premature exhaustion from the solution. Excessively high concentrations resulted in the formation of a dense layer of products hindering effective skin cleansing.
醇胺类物质在各种外用制剂中被广泛用作辅助物质。它们对皮肤皮脂成分的影响使它们能够用于清洁毛囊中皮脂的制剂中。我们测量了不同浓度的AMPD（2-氨基-2-甲基-1,3-丙二醇）水溶液对模拟皮肤皮脂的影响。使用两种方法计算反应皮脂的体积：通过光学评估醇胺与模拟皮肤皮脂成分的相互作用，以及根据AMPD溶液pH值变化的测量结果来确定模拟皮肤皮脂的反应体积。两种方法均表明，对模拟皮脂渗透最有利的AMPD浓度约为1-2%。醇胺浓度较低会导致溶液过早耗尽。浓度过高会形成致密的产物层，阻碍有效的皮肤清洁。
