Lee S, Iida M, Yao T, Shindo S, Fujishima M, Okabe H
Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Gastroenterology. 1988 Feb;94(2):381-6. doi: 10.1016/0016-5085(88)90425-8.
We investigated 2529 patients with peptic ulcer diagnosed from 1963 to 1975 to determine the prognosis relative to life span and causes of death. During the follow-up period of 9-23 yr, 486 patients (19.2%) died, 2025 (80.1%) were alive, and the fate of 18 (0.7%) was unknown. No significant differences were found between these numbers and the numbers expected from the sex- and age-matched general population at 1-20 yr after the initial diagnosis for patients with gastric ulcer, duodenal ulcer, or both gastric and duodenal ulcer, or for all ulcer groups combined. The survival rate for the surgically treated patients did not differ from the expected survival rate. The number of deaths from peptic ulcer (observed/expected = 18/5.47) was statistically high and the number from cerebrovascular disease was significantly low. Our results show that for patients with a peptic ulcer, the prognosis relative to life span is as good as that of the general population and surgery has little influence on the prognosis.
我们调查了1963年至1975年间诊断为消化性溃疡的2529例患者，以确定其相对于寿命的预后情况及死亡原因。在9至23年的随访期内，486例患者（19.2%）死亡，2025例（80.1%）存活，18例（0.7%）情况不明。对于胃溃疡、十二指肠溃疡、胃和十二指肠溃疡患者或所有溃疡组合并后的患者，在初次诊断后1至20年，这些数字与按性别和年龄匹配的普通人群预期数字之间未发现显著差异。手术治疗患者的生存率与预期生存率无差异。消化性溃疡导致的死亡人数（观察值/预期值 = 18/5.47）在统计学上偏高，而脑血管疾病导致的死亡人数显著偏低。我们的结果表明，对于消化性溃疡患者，相对于寿命的预后与普通人群一样好，手术对预后影响很小。
