Lee S, Iida M, Yao T, Shindo S, Nose Y, Akazawa K, Okabe H, Fujishima M
Dept. of Internal Medicine, Faculty of Medicine, Kyushu University, Japan.
Scand J Gastroenterol. 1990 Dec;25(12):1223-6. doi: 10.3109/00365529008998557.
We followed up 2072 patients with unoperated gastric and duodenal ulcer, diagnosed from 1963 to 1975, and evaluated the risk of development of gastric cancer. During the follow-up period of 9-23 years 38 patients had a gastric cancer or died of gastric cancer. The number of gastric cancers in patients with duodenal ulcer (observed/expected = 3:12) was statistically low (p less than 0.01) compared with the number expected from the sex- and age-matched general population. On the other hand, the number of patients with gastric ulcer and the number of those with both gastric and duodenal ulcers was 29 and 6, neither of which differed significantly from the expected occurrence. These results suggest that in peptic ulcer patients the risk of developing gastric cancer is equal to or low compared with that of the general population.
我们对1963年至1975年间诊断出的2072例未接受手术治疗的胃和十二指肠溃疡患者进行了随访，并评估了患胃癌的风险。在9至23年的随访期内，38例患者患胃癌或死于胃癌。与性别和年龄匹配的普通人群预期数量相比，十二指肠溃疡患者的胃癌数量（观察值/预期值 = 3:12）在统计学上较低（p小于0.01）。另一方面，胃溃疡患者数量以及同时患有胃和十二指肠溃疡的患者数量分别为29例和6例，两者与预期发生率均无显著差异。这些结果表明，与普通人群相比，消化性溃疡患者患胃癌的风险等于或较低。
