Sonnenberg A, Wasserman I H
Division of Gastroenterology, Medical College of Wisconsin, Milwaukee, USA.
Am J Public Health. 1995 Sep;85(9):1252-5. doi: 10.2105/ajph.85.9.1252.
The purpose of this study was to examine, through the database of the Department of Veterans Affairs, the joint occurrence of different diseases in individual patients.
Patients with a diagnosis of gastric cancer, gastric ulcer, or duodenal ulcer were extracted from the 1987 through 1990 computer files. A random sample of patients from each annual file served as a control population. All previous discharges of each case or control patient between 1970 and 1990 were searched for the occurrence of hypertensive diseases or chronic diseases of the joints, lungs, pancreas, and liver. The relative frequencies of such diagnoses in case and control patients were compared by multivariate logistic regression.
Gastric ulcer and duodenal ulcer, but not gastric cancer, were significantly associated with chronic diseases of the joints, lungs, pancreas, and liver. None of the three diagnoses showed any significant association with hypertensive diseases.
These relationships may reflect the influence of nonsteroidal anti-inflammatory drugs, smoking, and alcohol. They stress the importance of environmental risk factors other than Helicobacter pylori in terms of damage to the upper gastrointestinal mucosa.
本研究旨在通过退伍军人事务部的数据库，调查个体患者中不同疾病的联合发生情况。
从1987年至1990年的计算机文件中提取诊断为胃癌、胃溃疡或十二指肠溃疡的患者。从每年的文件中随机抽取患者作为对照人群。检索了1970年至1990年间每个病例或对照患者之前的所有出院记录，以查找高血压疾病或关节、肺、胰腺和肝脏的慢性疾病的发生情况。通过多变量逻辑回归比较病例组和对照组患者中此类诊断的相对频率。
胃溃疡和十二指肠溃疡，而非胃癌，与关节、肺、胰腺和肝脏的慢性疾病显著相关。这三种诊断均未显示与高血压疾病有任何显著关联。
这些关系可能反映了非甾体抗炎药、吸烟和饮酒的影响。它们强调了除幽门螺杆菌外的环境危险因素对上消化道黏膜损伤的重要性。
