Cho Yong-Bin, Lee In-Gu, Joo Yong-Hyun, Hong So-Hee, Seo Young-Jin
Department of Life Science, Chung-Ang University, Seoul 06974, Korea.
Department of Biotechnology, The Catholic University of Korea, Bucheon 14662, Korea.
Int J Mol Sci. 2020 Dec 18;21(24):9690. doi: 10.3390/ijms21249690.
Viral infectious diseases are a significant burden on public health and the global economy, and new viral threats emerge continuously. Since CD4 and CD8 T cell responses are essential to eliminating viruses, it is important to understand the underlying mechanisms of anti-viral T cell-mediated immunopathogenesis during viral infections. Remarkable progress in transgenic (Tg) techniques has enabled scientists to more readily understand the mechanisms of viral pathogenesis. T cell receptor (TCR) Tg mice are extremely useful in studying T cell-mediated immune responses because the majority of T cells in these mice express specific TCRs for partner antigens. In this review, we discuss the important studies utilizing TCR Tg mice to unveil underlying mechanisms of T cell-mediated immunopathogenesis during viral infections.
病毒性传染病对公共卫生和全球经济造成了重大负担，并且新的病毒威胁不断出现。由于CD4和CD8 T细胞反应对于清除病毒至关重要，因此了解病毒感染期间抗病毒T细胞介导的免疫发病机制的潜在机制非常重要。转基因（Tg）技术的显著进展使科学家能够更容易地理解病毒发病机制。T细胞受体（TCR）Tg小鼠在研究T细胞介导的免疫反应中非常有用，因为这些小鼠中的大多数T细胞表达针对伴侣抗原的特异性TCR。在这篇综述中，我们讨论了利用TCR Tg小鼠揭示病毒感染期间T细胞介导的免疫发病机制潜在机制的重要研究。
