Department of Gynecology, Gynecology Oncology and Obstetrics, Fryderyk Chopin University Hospital, F. Szopena 2, 35-055 Rzeszow, Poland.
Laboratory of Molecular Biology, Centre for Innovative Research in Medical and Natural Sciences, Medical College of Rzeszow University, Warzywna 1a, 35-959 Rzeszow, Poland.
Nutrients. 2023 Dec 31;16(1):144. doi: 10.3390/nu16010144.
Micronutrients are important components for the homeostasis of the human body. The studies available in the literature of the subject on their impact on the risk of population diseases, including malignant neoplasms, are ambiguous. In this paper, the relationship between Cu and Zn serum levels and the occurrence of endometrial cancer have been analyzed.
306 patients (153 test group and 153 control group) matched for age were analyzed for Cu and Zn levels. Microelements levels were determined for sera collected during the hospitalization of patients by means of an inductively coupled plasma mass spectrometry. In addition, the Cu/Zn ratio in the population included in the study was analyzed. Univariable and multivariable analyzes were used to examine the relationship between the factors under study and the incidence of endometrial cancer.
Lower levels of elements were observed in the study group compared with the control group (Cu: 959.39 μg/L vs. 1176.42 μg/L, < 0.001; Zn: 707.05 μg/L vs. 901.67 μg/L, < 0.001). A statistically significant relationship with the occurrence of endometrial cancer was observed for Cu and Zn. The patients with the lowest Cu level had a significantly higher occurrence of endometrial cancer compared with reference tertile (OR 8.54; < 0.001). Similarly, compared with the reference tertile, the patients with the lowest Zn levels had a significantly greater incidence of endometrial cancer (OR 15.0; < 0.001).
The results of the study suggest an association of endometrial cancer occurrence with lower Cu and Zn serum levels.
微量元素是人体内环境稳态的重要组成部分。目前该领域的文献研究表明，这些元素对人群疾病（包括恶性肿瘤）的风险影响并不明确。本文分析了血清铜（Cu）和锌（Zn）水平与子宫内膜癌发生之间的关系。
分析了 306 名患者（153 例实验组和 153 例对照组）的 Cu 和 Zn 水平，这些患者的年龄与病例相匹配。通过电感耦合等离子体质谱法检测患者住院期间采集的血清中的微量元素水平。此外，还分析了纳入研究人群的 Cu/Zn 比值。采用单变量和多变量分析方法，检验研究因素与子宫内膜癌发生率之间的关系。
与对照组相比，研究组的元素水平较低（Cu：959.39 μg/L 比 1176.42 μg/L，<0.001；Zn：707.05 μg/L 比 901.67 μg/L，<0.001）。Cu 和 Zn 与子宫内膜癌的发生呈显著相关。Cu 水平最低的患者发生子宫内膜癌的风险显著高于参考三分位（OR 8.54；<0.001）。同样，与参考三分位相比，Zn 水平最低的患者发生子宫内膜癌的风险显著更高（OR 15.0；<0.001）。
研究结果表明，血清 Cu 和 Zn 水平较低与子宫内膜癌的发生有关。
