Serban Dragos, Papanas Nikolaos, Dascalu Ana Maria, Stana Daniela, Nicolae Vanessa Andrada, Vancea Geta, Badiu Cristinel Dumitru, Tanasescu Denisa, Tudor Corneliu, Balasescu Simona Andreea, Pantea-Stoian Anca
University of Medicine and Pharmacy "Carol Davila" Bucharest, Bucharest, Romania.
Emergency University Hospital Bucharest, Bucharest, Romania.
Int J Low Extrem Wounds. 2021 Jun;20(2):98-103. doi: 10.1177/1534734620982237. Epub 2020 Dec 22.
This review discusses the evidence on diabetic retinopathy (DR) in patients with diabetic foot ulceration (DFU). A systematic literature review was performed on PubMed, Medline, Springer Nature, and Scopus, following the PRISMA guidelines, using the following terms, individually or in combination: "diabetic foot ulcer" OR "diabetic foot syndrome" OR "DFU" and "diabetic retinopathy." The initial search yielded 648 articles published between 1975 and 2020. After applying exclusion and inclusion criteria, a total of 9 articles were analyzed, assessing the correlations between DR and DFU. In all cases, DR and especially proliferative diabetic retinopathy were significantly higher in the presence of DFU, though the frequency of DR showed large variability (22.5% to 95.6%). There was a significant correlation between advanced stages of DFU and increased frequency of DR and proliferative diabetic retinopathy. On the other hand, there is a risk of accelerated progression of DR in nonhealing DFUs, possibly related to chronic inflammation and associated infection. Hence, patients with DFUs should be monitored by an ophthalmologist, and those with DR should be promptly referred to a specialized diabetic foot clinic.
本综述讨论了糖尿病足溃疡（DFU）患者糖尿病视网膜病变（DR）的相关证据。按照PRISMA指南，在PubMed、Medline、施普林格自然科学和Scopus数据库上进行了系统的文献综述，使用以下术语单独或组合检索：“糖尿病足溃疡”或“糖尿病足综合征”或“DFU”以及“糖尿病视网膜病变”。初步检索得到1975年至2020年间发表的648篇文章。在应用排除和纳入标准后，共分析了9篇文章，评估DR与DFU之间的相关性。在所有病例中，存在DFU时DR尤其是增殖性糖尿病视网膜病变的发生率显著更高，尽管DR的发生率差异很大（22.5%至95.6%）。DFU的晚期阶段与DR及增殖性糖尿病视网膜病变发生率增加之间存在显著相关性。另一方面，不愈合的DFU存在DR加速进展的风险，这可能与慢性炎症和相关感染有关。因此，DFU患者应由眼科医生进行监测，而DR患者应及时转诊至专业的糖尿病足诊所。
