Department of Ophthalmology, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China.
Int Wound J. 2023 Dec;20(10):4077-4082. doi: 10.1111/iwj.14299. Epub 2023 Aug 9.
This study aimed to explore the relationship between diabetic retinopathy (DR) and diabetic foot ulcers (DFUs) to provide evidence for the prevention of diabetic complications. PubMed, EMBASE, Web of Science, Cochrane Library, China National Knowledge Infrastructure, Chinese Biomedical Literature Database and Wanfang Data databases were searched from their inception until March 2023 for studies on the relationship between DR and DFU. Two researchers independently screened the literature and extracted data according to the inclusion and exclusion criteria. The meta-analysis was performed using the RevMan 5.3 software. Eleven articles referring to 10 208 patients were included, of whom 2191 patients had DFU and 8017 patients did not have DFU. The meta-analysis results showed that DR significantly increased the incidence of DFU (47.94% vs. 16.38%; OR, 4.13; 95% CI, 2.33-7.33; p < 0.001). The results of this study suggest that patients with DR have a higher risk of developing DFU, highlighting the importance of regular screening for these two complications to prevent serious adverse outcomes of diabetes. However, further high-quality studies are required to validate the conclusions of the present study.
本研究旨在探讨糖尿病视网膜病变（DR）与糖尿病足溃疡（DFU）之间的关系，为预防糖尿病并发症提供证据。检索了 PubMed、EMBASE、Web of Science、Cochrane 图书馆、中国知网、中国生物医学文献数据库和万方数据数据库，从建库至 2023 年 3 月，检索关于 DR 与 DFU 关系的研究。两名研究人员根据纳入和排除标准独立筛选文献并提取数据。使用 RevMan 5.3 软件进行荟萃分析。纳入了 11 篇涉及 10208 名患者的文章，其中 2191 名患者患有 DFU，8017 名患者没有 DFU。荟萃分析结果表明，DR 显著增加了 DFU 的发生率（47.94%比 16.38%；OR，4.13；95%CI，2.33-7.33；p<0.001）。本研究结果表明，DR 患者发生 DFU 的风险更高，这突出了定期筛查这两种并发症以预防糖尿病严重不良结局的重要性。然而，需要进一步开展高质量的研究来验证本研究的结论。
