Xu James Haiyang, Coo Helen, Fucile Sandra, Ng Eugene, Ting Joseph Y, Shah Prakesh S, Dow Kimberly
Department of Pediatrics, Queen's University, Kingston, Ontario.
Department of Paediatrics, University of Toronto, Toronto, Ontario.
Paediatr Child Health. 2019 Aug 30;25(8):529-533. doi: 10.1093/pch/pxz112. eCollection 2020 Dec.
Nutrition affects the growth and neurodevelopmental outcomes of preterm infants, yet controversies exist about the optimal enteral feeding regime. The objective of this study was to compare enteral feeding guidelines in Canadian neonatal intensive care units (NICUs).
The research team identified key enteral feeding practices of interest. Canadian Neonatal Network site investigators at 30 Level 3 NICUs were contacted to obtain a copy of their 2016 to 2017 feeding guidelines for infants who weighed less than 1,500 g at birth. Each guideline was reviewed to compare recommendations around the selected feeding practices.
Five of the 30 NICUs did not have a feeding guideline. The other 25 NICUs used 22 different enteral feeding guidelines. The guidelines in 40% of those NICUs recommend commencing minimal enteral nutrition (MEN) within 24 hours of birth and maintaining that same feeding volume for 24 to 96 hours. In 40% of NICUs, the guideline recommended that MEN be initiated at a volume of 5 to 10 mL/kg/day for infants born at <1,000 g. Guidelines in all 25 NICUs recommend the use of bovine-based human milk fortifier (HMF), and in 56% of NICUs, it is recommended that HMF be initiated at a total fluid intake of 100 mL/kg/day. Guidelines in only 16% of NICUs recommended routine gastric residual checks. Donor milk and probiotics are used in 76% and 72% of the 25 NICUs, respectively.
This study revealed substantial variability in recommended feeding practices for very low birth weight infants, underscoring the need to establish a national feeding guideline for this vulnerable group.
营养会影响早产儿的生长及神经发育结局,但关于最佳肠内喂养方案仍存在争议。本研究的目的是比较加拿大新生儿重症监护病房(NICU)的肠内喂养指南。
研究团队确定了感兴趣的关键肠内喂养做法。联系了30家三级NICU的加拿大新生儿网络站点调查人员,以获取其2016至2017年针对出生体重小于1500g婴儿的喂养指南副本。对每份指南进行审查,以比较所选喂养做法的相关建议。
30家NICU中有5家没有喂养指南。其他25家NICU使用了22种不同的肠内喂养指南。其中40%的NICU指南建议在出生后24小时内开始微量肠内营养(MEN),并在24至96小时内维持相同的喂养量。在40%的NICU中,指南建议对于出生体重<1000g的婴儿,以5至10mL/kg/天的量开始MEN。所有25家NICU的指南都推荐使用基于牛的母乳强化剂(HMF),56%的NICU建议在总液体摄入量达到100mL/kg/天时开始使用HMF。只有16%的NICU指南建议进行常规胃残余量检查。25家NICU中分别有76%和72%使用捐赠母乳和益生菌。
本研究揭示了极低出生体重婴儿推荐喂养做法的显著差异,强调了为这一弱势群体制定全国性喂养指南的必要性。