Thorpy M J, Korman E, Spielman A J, Glovinsky P B
Department of Neurology, Montefiore Medical Center, Bronx, NY 10467.
J Adolesc Health Care. 1988 Jan;9(1):22-7. doi: 10.1016/0197-0070(88)90014-9.
The delayed sleep phase syndrome is characterized by difficulty in falling asleep at a socially acceptable time of night and an inability to be easily aroused in the morning. Most commonly encountered in adolescents, this condition can produce daytime sleepiness and poor school performance, and it can lead to behavioral problems. The clinical features of the syndrome are described in 22 adolescents. Nine subjects participated in a protocol of polysomnographic recordings to simulate habitual "weekday" and "weekend" sleep patterns. There was a significant increase in total sleep time (p less than 0.005) and REM sleep (p less than 0.001) during the "weekend" sleep period. A multiple sleep latency test was performed between the two nights to assess daytime sleep tendency. Daytime sleepiness was maximal in the morning, with a tendency for greater alertness as the day progressed. The reduced amount of REM sleep during the "weekdays" plus the tendency for sleepiness in the mornings may contribute to the behavioral and educational difficulties seen in these patients. Recognition of this syndrome enables a specific sleep schedule change to be made that effectively treats the problem.
延迟睡眠相位综合征的特征是在社会认可的夜间入睡时间难以入睡，且早晨难以轻易醒来。这种情况最常出现在青少年中，会导致白天嗜睡、学业表现不佳，并可能引发行为问题。文中描述了22名青少年该综合征的临床特征。9名受试者参与了一项多导睡眠图记录方案，以模拟习惯性的“工作日”和“周末”睡眠模式。在“周末”睡眠期间，总睡眠时间（p<0.005）和快速眼动睡眠（p<0.001）显著增加。在两晚之间进行了多次睡眠潜伏期测试，以评估白天的睡眠倾向。白天嗜睡在早晨最为严重，随着一天的进展，警觉性有提高的趋势。“工作日”期间快速眼动睡眠量减少以及早晨嗜睡的倾向可能导致了这些患者出现行为和教育方面的困难。认识到这种综合征后，可以制定特定的睡眠时间表改变，从而有效治疗该问题。
