Li C C, Lyu Y B, Chen C, Zhang X C, Cai J F, Zhou J H, Gu H, Cao Z J, Zhao F, Lu F, Liu Y C, Shi X M
China CDC Key Laboratory of Environment and Population Health/National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China.
Beijing Municipal Health Commission Information Center/Beijing Municipal Health Commission Policy Research Center, Beijing 100034, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2021 Jan 6;55(1):60-65. doi: 10.3760/cma.j.cn112150-20200720-01028.
To investigate the association of blood arsenic level with hyperuricemia among elderly aged 65 years and older. Data was collected in 9 longevity areas from Heathy Aging and Biomarkers Cohort Study between 2017 and 2018. 2 438 participants aged 65 years and older with complete information on blood arsenic and uric acid were included in this study. Information including demographics characteristic, life style and health status was collected by questionnaire and physical examination. Meanwhile, venous blood was collected to detect the levels of blood arsenic and uric acid. Subjects were stratified into three groups (low, middle and high) by tertiles of blood arsenic level. Logistic regression models were used to analyze the association of blood arsenic level with hyperuricemia. The age of participants was (84.57±11.41) years, of which 1 172 (48.07%) were male and 1 525 (62.55%) were over 80 years old. The detection rate of hyperuricemia was 17.23% (420), and the detection rates of hyperuricemia were 11.77%, 19.25% and 20.62% among participants with low, middle and high blood arsenic, respectively (<0.001). After controlling confounding factors, compared with participants who had low blood arsenic, the s (95%) of hyperuricemia for the participants with middle and high blood arsenic were 1.57 (1.12-2.23) and 2.08 (1.46-2.99), respectively. Subgroups analysis showed that compared with female, the association between blood arsenic level and hyperuricemia was more obvious in males (<0.05). Blood arsenic level is associated with the risk for hyperuricemia among the elderly aged 65 years and older in 9 longevity areas in China.
探讨65岁及以上老年人血砷水平与高尿酸血症的关联。2017年至2018年期间，从健康老龄化与生物标志物队列研究的9个长寿地区收集数据。本研究纳入了2438名65岁及以上且血砷和尿酸信息完整的参与者。通过问卷调查和体格检查收集包括人口统计学特征、生活方式和健康状况等信息。同时，采集静脉血检测血砷和尿酸水平。根据血砷水平三分位数将受试者分为三组（低、中、高）。采用逻辑回归模型分析血砷水平与高尿酸血症的关联。参与者年龄为（84.57±11.41）岁，其中男性1172名（48.07%），80岁以上者1525名（62.55%）。高尿酸血症检出率为17.23%（420例），血砷水平低、中、高的参与者中高尿酸血症检出率分别为11.77%、19.25%和20.62%（P<0.001）。在控制混杂因素后，与血砷水平低的参与者相比，血砷水平中等和高的参与者患高尿酸血症的比值比（95%可信区间）分别为1.57（1.12 - 2.23）和2.08（1.46 - 2.99）。亚组分析显示，与女性相比，血砷水平与高尿酸血症的关联在男性中更明显（P<0.05）。中国9个长寿地区65岁及以上老年人血砷水平与高尿酸血症风险相关。
