Tan Q Y, Lyu Y B, Zhou J H, Zhang M Y, Chen C, Zhao F, Li C C, Qu Y L, Ji S S, Lu F, Liu Y C, Gu H, Wu B, Cao Z J, Zhao S H, Shi X M
China CDC Key Laboratory of Environment and Population Health/National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China.
School of Public Health, Jilin University, Changchun 130012, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2021 Jan 6;55(1):18-24. doi: 10.3760/cma.j.cn112150-20200728-01065.
To investigate the association of blood oxidative stress level with hypertriglyceridemia in the elderly aged 65 years and older in China. A total of 2 393 participants aged 65 years and older were recruited in 9 longevity areas from Heathy Aging and Biomarkers Cohort Study, during 2017 to 2018. Information on demographics characteristic, life style and health status were collected by questionnaire and physical examination, and venous blood was collected to detect the levels of blood oxidative stress and hypertriglyceridemia. The linear or non-linear association between oxidative stress and hypertriglyceridemia was described by restrictive cubic splines (RCS) fitting multiple linear regression model. The generalized linear mixed effect model was conducted to assess the association between oxidative stress and hypertriglyceridemia. A total of 2 393 participants, mean age was 84.6 years, the youngest was 65 and the oldest was 112, the male was 47.9%(1 145/2 393), the triglyceride level was (1.4±0.8) mmol/L. The hypertriglyceridemia detection rate was 9.99%(239/2 393). The results of multiple linear regression model with restrictive cubic spline fitting showed that MDA level was linear association with triglyceride level; SOD level was nonlinear association with triglyceride level. MDA level had significantly association with hypertriglyceridemia, and the corresponding value was 1.063 (95%: 1.046,1.081) with 1 nmol/ml increment of blood MDA; SOD level had significantly association with hypertriglyceridemia, and the corresponding value was 0.986(95%: 0.983,0.989) with 1 U/ml increment of blood SOD. Among the elderly aged 65 and older in 9 longevity areas in China, MDA and SOD levels were associated with the risk of hypertriglyceridemia.
探讨中国65岁及以上老年人血液氧化应激水平与高甘油三酯血症的关联。2017年至2018年期间，从健康老龄化与生物标志物队列研究中选取了9个长寿地区的2393名65岁及以上参与者。通过问卷调查和体格检查收集人口统计学特征、生活方式和健康状况信息，并采集静脉血检测血液氧化应激和高甘油三酯血症水平。采用限制性立方样条（RCS）拟合多元线性回归模型描述氧化应激与高甘油三酯血症之间的线性或非线性关联。采用广义线性混合效应模型评估氧化应激与高甘油三酯血症之间的关联。共有2393名参与者，平均年龄为84.6岁，年龄最小为65岁，最大为112岁，男性占47.9%（1145/2393），甘油三酯水平为（1.4±0.8）mmol/L。高甘油三酯血症检出率为9.99%（239/2393）。限制性立方样条拟合的多元线性回归模型结果显示，丙二醛（MDA）水平与甘油三酯水平呈线性关联；超氧化物歧化酶（SOD）水平与甘油三酯水平呈非线性关联。MDA水平与高甘油三酯血症显著相关，血液MDA每增加1 nmol/ml，相应比值为1.063（95%：1.046，1.081）；SOD水平与高甘油三酯血症显著相关，血液SOD每增加1 U/ml，相应比值为0.986（95%：0.983，0.989）。在中国9个长寿地区的65岁及以上老年人中，MDA和SOD水平与高甘油三酯血症风险相关。
