Chen C, Lyu Y B, Li C C, Cai J F, Zhang X C, Liu Y C, Lu F, Zhao F, Cao Z J, Shi X M
China CDC Key Laboratory of Environment and Population Health/National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China.
Beijing Municipal Health Commission Information Center/Beijing Municipal Health Commission Policy Research Center, Beijing 100034, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2021 Jan 6;55(1):39-44. doi: 10.3760/cma.j.cn112150-20200724-01053.
To examine the association of blood uric acid (UA) and cognitive impairment (CI) among oldest-old adults in China. Data was collected in 9 longevity areas of China from Healthy Aging and Biomarkers Cohort Study (HABCS) conducted during 2017-2018. Finally,1, 622 elderly aged 80 years and older with complete information on blood UA and cognitive function score were included in this study. Information on demographic characteristics, lifestyle, and health status were collected through questionnaire and physical examination. Venous blood samples of the participants were collected to test blood UA level. Cognitive impairment (CI) was assessed using the Chinese Mini-Mental State Examination (MMSE) according to personal educational level. Generalized Estimating Equations (GEE) model for binary data was used to analyze the association of blood UA and CI, and further compared the associations among different age and body mass index (BMI) groups. Of the 1 622 oldest-old, the mean age was (92.2±8.1) years, 656 (40.4%) were male, the mean level of blood UA was (343.3±86.2) μmol/L, and 482 (29.7%) oldest-old had CI. Compared with the lowest quartile of UA, the risks of CI in the second, third and highest quartiles were gradually reduced, the corresponding s and 95% were 0.99 (0.71-1.33), 0.87 (0.68-0.94) and 0.69 (0.48-0.85), respectively; and the linear trend test was statistically significant (<0.001). Subgroup analysis showed that the effects of higher UA associated with lower risk of CI were stronger in younger oldest-old (aged 80-89 years) and thinner group (BMI<24) (<0.05). Blood UA was negatively associated with the risk of having CI in the oldest-old among the nine longevity areas of China.
探讨中国高龄老年人血尿酸（UA）与认知功能障碍（CI）之间的关联。数据来自于2017 - 2018年在中国9个长寿地区开展的健康老龄化与生物标志物队列研究（HABCS）。最终，本研究纳入了1622名80岁及以上且血尿酸和认知功能评分信息完整的老年人。通过问卷调查和体格检查收集了人口统计学特征、生活方式和健康状况等信息。采集参与者的静脉血样本以检测血尿酸水平。根据个人教育水平，使用中文版简易精神状态检查表（MMSE）评估认知功能障碍（CI）。采用二元数据的广义估计方程（GEE）模型分析血尿酸与CI之间的关联，并进一步比较不同年龄和体重指数（BMI）组之间的关联。在这1622名高龄老年人中，平均年龄为（92.2±8.1）岁，男性656名（40.4%），血尿酸平均水平为（343.3±86.2）μmol/L，482名（29.7%）高龄老年人患有CI。与血尿酸最低四分位数组相比，第二、第三和最高四分位数组的CI风险逐渐降低，相应的比值比及95%置信区间分别为0.99（0.71 - 1.33）、0.87（0.68 - 0.94）和0.69（0.48 - 0.85）；线性趋势检验具有统计学意义（P<0.001）。亚组分析表明，在年龄较轻的高龄老年人（80 - 八十九岁）和较瘦组（BMI<24）中，较高血尿酸与较低CI风险的关联更强（P<0.05）。在中国9个长寿地区的高龄老年人中，血尿酸与CI风险呈负相关。
