Qian Xiao-Xin, Liu Yan, Wang Hao, Qi Nian-Min
Shanghai Quansheng Bio-Tech Co., Ltd., Shanghai 200120, China.
Shanghai Kunli Bio-Tech Co., Ltd., Shanghai 201318, China.
Zhonghua Nan Ke Xue. 2020 Jun;26(6):564-569.
Mesenchymal stem cells (MSC), as a type of multifunction cells capable of self-renewal and multi-directional differentiation and with a low immunogenicity, have been widely applied in life sciences and medicine in recent years. Male infertility is very complicated pathogenically and there is no ideal method for its treatment. The potential ability of multi-differentiation and paracrine function of MSCs is bringing new hope to patients with male infertility. MSCs can be derived from the bone marrow, adipose tissue, and umbilical cord, on which lots of studies, either in vitro or in vivo, have been conducted and achieved satisfactory results. Many findings indicate that MSCs can differentiate into germ-like cells if specifically induced or transplanted into the testis, improve the local microenvironment of spermatogenesis and reconstruct the spermatogenic process by secreting nutritional factors after transplantation. This article presents an overview of the advances in the studies and application prospects of MSCs in male infertility.
间充质干细胞（MSC）作为一类能够自我更新、多向分化且免疫原性低的多功能细胞，近年来在生命科学和医学领域得到了广泛应用。男性不育的发病机制非常复杂，目前尚无理想的治疗方法。MSC的多向分化潜能和旁分泌功能为男性不育患者带来了新的希望。MSC可来源于骨髓、脂肪组织和脐带，针对这些来源的MSC已经开展了大量的体内外研究，并取得了令人满意的结果。许多研究结果表明，MSC经特定诱导或移植到睾丸后可分化为类生殖细胞，移植后通过分泌营养因子改善生精局部微环境并重建生精过程。本文综述了MSC在男性不育研究方面的进展及其应用前景。
