Chang Zhuo, Zhu Hui, Zhou Xueming, Zhang Yang, Jiang Bei, Li Shuoxi, Chen Lu, Pan Xue, Feng Xiao-Ling
Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, China.
First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, China.
Stem Cells Int. 2021 May 17;2021:8882368. doi: 10.1155/2021/8882368. eCollection 2021.
Infertility is a global reproductive disorder which is caused by a variety of complex diseases. Infertility affects the individual, family, and community through physical, psychological, social and economic consequences. The results from recent preclinical studies regarding stem cell-based therapies are promising. Stem cell-based therapies cast a new hope for infertility treatment as a replacement or regeneration strategy. The main features and application prospects of mesenchymal stem cells in the future of infertility should be understood by clinicians. Mesenchymal stem cells (MSCs) are multipotent stem cells with abundant source, active proliferation, and multidirectional differentiation potential. MSCs play a role through cell homing, secretion of active factors, and participation in immune regulation. Another advantage is that, compared with embryonic stem cells, there are fewer ethical factors involved in the application of MSCs. However, a number of questions remain to be answered prior to safe and effective clinical application. In this review, we summarized the recent status of MSCs in the application of the diseases related to or may cause to infertility and suggest a possible direction for future cytotherapy to infertility.
不孕症是一种全球性的生殖系统疾病，由多种复杂病症引起。不孕症通过生理、心理、社会和经济方面的影响，波及个人、家庭及社会。近期有关基于干细胞疗法的临床前研究成果令人期待。基于干细胞的疗法作为一种替代或再生策略，为不孕症治疗带来了新希望。临床医生应了解间充质干细胞在未来不孕症治疗中的主要特性及应用前景。间充质干细胞（MSCs）是多能干细胞，来源丰富，增殖活跃，具有多向分化潜能。MSCs通过细胞归巢、分泌活性因子以及参与免疫调节发挥作用。另一个优势是，与胚胎干细胞相比，MSCs应用涉及的伦理因素较少。然而，在安全有效地应用于临床之前，仍有诸多问题有待解答。在本综述中，我们总结了MSCs在与不孕症相关或可能导致不孕症的疾病应用中的最新研究状况，并为未来不孕症细胞治疗提出了可能的方向。
