Department of Biology, Faculty of Science, University of Mohaghegh Ardabili, Ardabil, Iran.
Department of Engineering Sciences, Faculty of Advanced Technologies, University of Mohaghegh Ardabili, Namin, Iran.
Br J Neurosurg. 2024 Apr;38(2):301-306. doi: 10.1080/02688697.2020.1864292. Epub 2020 Dec 26.
Peripheral nerve injury is a common clinical disorder. The aim of the present study was to investigate the role of cerium oxide nanoparticles on axonal regeneration and functional recovery of the sciatic nerve after a crush injury in the rat model.
A total of 40 adult male Wistar rats were divided into four groups. The animals underwent deep anesthesia. Afterward, the right sciatic nerve of rats was exposed and crushed. In two experimental groups, rats were treated intraperitoneally with cerium oxide nanoparticles at the dosage of 20 or 80 mg/kg daily for 1 week. The control group was given a vehicle. Then, during the nerve regeneration motor and sensory function recovery tests, histomorphometric evaluations, histological assessment of gastrocnemius muscle, and gastrocnemius muscle wet weights tests were performed.
Results demonstrated that the rate of nerve regeneration increased with the administration of cerium oxide nanoparticle in high doses. Also, the morphometric analysis showed that the number of myelinated fibers and myelin sheath thicknesses was significantly greater in the cerium oxide nanoparticle group versus the control group. Other parameters also improved in the cerium oxide nanoparticle treatment groups compared with the control group.
These data indicate that this nanoparticle has therapeutic potential and can be considered as a new treatment for nervous system regeneration.
周围神经损伤是一种常见的临床疾病。本研究旨在探讨氧化铈纳米粒子在大鼠挤压伤模型中对轴突再生和坐骨神经功能恢复的作用。
将 40 只成年雄性 Wistar 大鼠分为四组。动物行深度麻醉后暴露右侧坐骨神经并挤压。在两个实验组中，大鼠每日腹腔内给予氧化铈纳米粒子 20 或 80mg/kg，持续 1 周。对照组给予载体。然后，在神经再生运动和感觉功能恢复测试期间，进行组织形态计量评估、比目鱼肌组织学评估和比目鱼肌湿重测试。
结果表明，氧化铈纳米粒子的给药剂量增加可提高神经再生率。形态计量分析还表明，与对照组相比，氧化铈纳米粒子组有髓纤维数量和髓鞘厚度明显增加。与对照组相比，氧化铈纳米粒子治疗组的其他参数也有所改善。
这些数据表明，该纳米粒子具有治疗潜力，可考虑作为神经系统再生的新治疗方法。
