植物蛋白 P3IP 参与. 自噬的调控。
Plant protein P3IP participates in the regulation of autophagy in .
机构信息
State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Institute of Plant Virology, Ningbo University , Ningbo, China.
MOE Key Laboratory of Bioinformatics, Center for Plant Biology, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University , Beijing, China.
出版信息
Plant Signal Behav. 2021 Mar 4;16(3):1861768. doi: 10.1080/15592324.2020.1861768. Epub 2020 Dec 23.
Autophagy, a bulk degradation system conserved among most eukaryotes, is also involved in responses to viral infection in plant. In our previous study, a new host factor P3IP was identified to interact with RSV (rice stripe virus) p3 and mediate its autophagic degradation to limit the viral infection. Here, we further discovered that P3IP of (NbP3IP) participated in regulation of autophagy. Overexpression of NbP3IP induced autophagy and down-regulation of NbP3IP reduced autophagy. Combined the functions of autophagy-mediated plant defense against plant virus and regulation autophagy, we indicate that P3IP participates in the regulation of autophagy.
自噬是一种在大多数真核生物中保守的大规模降解系统，也参与植物对病毒感染的反应。在我们之前的研究中，发现了一个新的宿主因子 P3IP，它与 RSV（水稻条纹病毒）p3 相互作用并介导其自噬降解，以限制病毒感染。在这里，我们进一步发现，NbP3IP 的 P3IP 参与了自噬的调节。NbP3IP 的过表达诱导自噬，而 NbP3IP 的下调减少自噬。结合自噬介导的植物抗病毒防御功能和自噬调节功能，我们表明 P3IP 参与了自噬的调节。
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