Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , China.
Department of Anesthesia, First Hospital of China Medical University, China Medical University , Shenyang , China.
Cancer Biol Ther. 2019;20(9):1163-1171. doi: 10.1080/15384047.2019.1617563. Epub 2019 May 28.
There is currently no diagnostic modality for early-stage pancreatic cancer. Given that adjuvant therapies require further development, the overall survival of pancreatic cancer remains unsatisfactory. Circular RNAs (circRNAs) are a class of noncoding RNAs that play an important role in the progression of many diseases including cancer. CircRNAs mainly bind to microRNAs as microRNA sponges to restore the expression of targeted genes and regulate tumor invasion, metastasis, proliferation, and apoptosis. CircRNAs also play roles in the diagnosis and targeted therapy of tumors. Studies on the mechanisms of action of circRNAs in pancreatic cancer are still in their infancy, but it is anticipated that this field will gradually advance. In this review, we provide a brief introduction to circRNAs from four perspectives: biogenesis, functions, and mechanisms of action, tumor therapy with circRNAs, and circRNAs' roles in pancreatic cancer.
目前尚无用于早期胰腺癌的诊断方法。由于辅助疗法需要进一步发展，胰腺癌的总体生存率仍然不尽如人意。环状 RNA（circRNA）是一类非编码 RNA，在包括癌症在内的许多疾病的进展中发挥着重要作用。circRNA 主要作为 microRNA 海绵与 microRNAs 结合，从而恢复靶基因的表达，并调节肿瘤的侵袭、转移、增殖和凋亡。circRNA 也在肿瘤的诊断和靶向治疗中发挥作用。circRNA 在胰腺癌中的作用机制的研究仍处于起步阶段，但预计这一领域将逐渐取得进展。在这篇综述中，我们从四个方面简要介绍了 circRNA：生物发生、功能和作用机制、circRNA 肿瘤治疗以及 circRNA 在胰腺癌中的作用。
