Campion E W, deLabry L O, Glynn R J
Geriatrics Unit, Massachusetts General Hospital, Boston.
J Gerontol. 1988 Jan;43(1):M18-20. doi: 10.1093/geronj/43.1.m18.
To clarify the relation between age and serum albumin, measures were obtained on a screened population of 1066 healthy males in the Normative Aging Study. Multiple regression analysis shows only a slight decline in albumin of 0.054 gm/dl per decade with R = -0.12 (p less than .001) on cross-sectional data. This small decline occurs entirely within the range of normal, contrary to many previous reports. Mean albumin values were 4.25 (+/- .26 SD) for subjects in the eighth decade and 4.13 (+/- .29 SD) in the ninth decade. Longitudinally, there was an upwards trend in albumin for five birth cohorts over an 8-yr period which may reflect laboratory drift. A multivariate model of cross-sectional data can explain only 5% of the variance. The age-related decline within healthy subjects is far less than previously described. Our data demonstrate that hypoalbuminemia is not a consequence of normal aging.
为了阐明年龄与血清白蛋白之间的关系，在规范衰老研究中对1066名健康男性的筛查人群进行了测量。多元回归分析显示，根据横断面数据，白蛋白每十年仅轻微下降0.054克/分升，相关系数R = -0.12（p小于0.001）。与许多先前的报告相反，这种小幅下降完全发生在正常范围内。第八个十年的受试者平均白蛋白值为4.25（±0.26标准差），第九个十年为4.13（±0.29标准差）。纵向来看，五个出生队列在8年期间白蛋白呈上升趋势，这可能反映了实验室偏差。横断面数据的多变量模型只能解释5%的方差。健康受试者中与年龄相关的下降远低于先前描述的情况。我们的数据表明，低白蛋白血症不是正常衰老的结果。
