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牛奶中的促性腺激素释放激素。

Gonadotropin-releasing hormone in milk.

作者信息

Baram T, Koch Y, Hazum E, Fridkin M

出版信息

Science. 1977 Oct 21;198(4314):300-2. doi: 10.1126/science.333582.

DOI:10.1126/science.333582
PMID:333582
Abstract

The hypothalamic hormone gonadotropin-releasing hormone (GnRH) has been found in milk of man, cow, and rat. Radioimmunoassays of acidified milk indicate concentrations of GnRH ranging between 0.1 and 3 nanograms per milliliter. Multistep extractions, followed by electrophoresis, reveal gonadotropin-releasing activity in the fraction that comigrates with the GnRH-marker. A second hypothalamic hormone, thyrotropin-releasing hormone, is present in milk at a much lower concentration. "Milk -GnRH" may influence the secretion of the gonadotropic hormones in neonates.

摘要

已在人、牛和大鼠的乳汁中发现下丘脑激素促性腺激素释放激素(GnRH)。对酸化乳汁进行放射免疫分析表明,GnRH的浓度在每毫升0.1至3纳克之间。经过多步提取,然后进行电泳,发现在与GnRH标记物一同迁移的组分中存在促性腺激素释放活性。另一种下丘脑激素促甲状腺激素释放激素在乳汁中的浓度要低得多。“乳汁中的GnRH”可能会影响新生儿促性腺激素的分泌。

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2
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Regulation of gonadotropin subunit messenger ribonucleic acid expression in gonadotropin-releasing hormone (GnRH)-deficient female rats: effects of GnRH, galanin, GnRH-associated peptide, neuropeptide-Y, and thyrotropin-releasing hormone.促性腺激素释放激素(GnRH)缺乏雌性大鼠中促性腺激素亚基信使核糖核酸表达的调节:GnRH、甘丙肽、GnRH相关肽、神经肽Y和促甲状腺激素释放激素的作用。
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The potential physiological significance of milk-borne hormonally active substances for the neonate.母乳中携带的激素活性物质对新生儿潜在的生理意义。
J Mammary Gland Biol Neoplasia. 1996 Jul;1(3):317-23. doi: 10.1007/BF02018084.
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GnRH receptors in human breast cancer and its contiguous not-involved breast tissue.人乳腺癌及其相邻未受累乳腺组织中的促性腺激素释放激素受体
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The gene for the neuropeptide gonadotropin-releasing hormone is expressed in the mammary gland of lactating rats.神经肽促性腺激素释放激素的基因在泌乳大鼠的乳腺中表达。
Proc Natl Acad Sci U S A. 1994 May 24;91(11):4994-6. doi: 10.1073/pnas.91.11.4994.
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Experientia. 1984 Jul 15;40(7):757-8. doi: 10.1007/BF01949764.
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Acta Acad Med Wuhan. 1984;4(2):90-4. doi: 10.1007/BF02857025.
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