Gungor Kobat S, Yusufoglu E, Gul F C, Celik F, Kalayci M
Elazıg Health Science University, Department of Ophthalmology, Elazıg, Turkey.
Elazıg Health Science University, Department of Ophthalmology, Elazıg, Turkey.
J Fr Ophtalmol. 2021 Feb;44(2):218-223. doi: 10.1016/j.jfo.2020.02.034. Epub 2020 Dec 25.
To evaluate levels of plasma cerebellin, cortisol, adrenaline and noradrenaline in patients with central serous chorioretinopathy (CSC).
This prospective study included 30 patients diagnosed with acute CSC (Group 1) and a control group of 30 age-matched, healthy subjects without CSC (Group 2). Levels of plasma cerebellin, cortisol, adrenaline and noradrenaline were examined in blood samples taken after 8-12hours of fasting. A value of p<0.05 was considered statistically significant in the comparative analyses.
The mean plasma cerebellin level was found to be 232.56±113.28 pg/ml in Group 1 and 174.07±82.04 pg/ml in Group 2 (p=0.02). Mean plasma cortisol was 13.19±3.87μg/ml in Group 1 and 9.55±2.92μg/ml in Group 2 (p<0.01). Mean plasma adrenaline was 60.62±26.67 pg/ml in Group 1 and 46.17±19.20 pg/ml in Group 2 (p=0.03). Mean plasma noradrenaline was 206.66±73.90 pg/ml in Group 1 and 149.96±51.36 pg/ml in Group 2 (p<0.01).
It can be concluded that increased cerebellin may have a role in the etiology of CSC by increasing catecholamine expression from the adrenal medulla and indirectly by increasing cortisol levels via a paracrine effect from the adrenal cortex.
评估中心性浆液性脉络膜视网膜病变（CSC）患者血浆小脑素、皮质醇、肾上腺素和去甲肾上腺素的水平。
这项前瞻性研究纳入了30例被诊断为急性CSC的患者（第1组）和30例年龄匹配、无CSC的健康对照者（第2组）。在禁食8 - 12小时后采集的血样中检测血浆小脑素、皮质醇、肾上腺素和去甲肾上腺素的水平。在比较分析中，p<0.05的值被认为具有统计学意义。
第1组血浆小脑素平均水平为232.56±113.28 pg/ml，第2组为174.07±82.04 pg/ml（p = 0.02）。第1组血浆皮质醇平均水平为13.19±3.87μg/ml，第2组为9.55±2.92μg/ml（p<0.01）。第1组血浆肾上腺素平均水平为60.62±26.67 pg/ml，第2组为46.17±19.20 pg/ml（p = 0.03）。第1组血浆去甲肾上腺素平均水平为206.66±73.90 pg/ml，第2组为149.96±51.36 pg/ml（p<0.01）。
可以得出结论，小脑素增加可能通过增加肾上腺髓质的儿茶酚胺表达，并通过肾上腺皮质的旁分泌作用间接增加皮质醇水平，从而在CSC的病因学中发挥作用。
