Elazig Health Science University, Department of Ophthalmology, Elazig, Turkey.
Elazig Health Science University, Department of Ophthalmology, Elazig, Turkey.
J Fr Ophtalmol. 2021 May;44(5):621-625. doi: 10.1016/j.jfo.2020.08.032. Epub 2021 Apr 15.
To evaluate plasma dopamine and catecholamine levels in patients with central serous chorioretinopathy (CSCR).
In this prospective study, 32 patients with acute CSCR were included, along with 32 age- and gender-matched healthy controls without CSCR. Complete ophthalmologic examinations were performed. Plasma dopamine, epinephrine, norepinephrine levels were measured in the morning after 8-12hours of fasting. A P-value of less than 0.05 was considered statistically significant.
While the mean age of the CSCR group was 40.12±7.96 years, the mean age of the control group was 37.81±7.26 years. There was no statistically significant difference between the groups in terms of age or gender (P=0.229, P=0.740, respectively). The plasma dopamine level was 29.85±9.39pg/ml in the CSCR group and 23.93±7.33pg/ml in the control group (P=0.001). The plasma epinephrine level was 60.73±25.69pg/ml in the CSCR group and 45.77±18.55pg/ml in the control group (P=0.021). The plasma norepinephrine level was 206.68±71.51pg/ml in the CSCR group and 149.33±49.69pg/ml in the control group (P=0.001). Plasma dopamine, epinephrine, and norepinephrine levels were statistically significantly higher in the CSCR group.
We concluded that dopamine may be a possible factor in the etiology of CSCR, both through its receptors and by enhancing sympathetic activity.
评估中心性浆液性脉络膜视网膜病变（CSCR）患者的血浆多巴胺和儿茶酚胺水平。
在这项前瞻性研究中，纳入了 32 例急性 CSCR 患者和 32 名年龄和性别匹配的无 CSCR 的健康对照者。进行了全面的眼科检查。在禁食 8-12 小时后，于早晨测量血浆多巴胺、肾上腺素、去甲肾上腺素水平。P 值小于 0.05 被认为具有统计学意义。
CSCR 组的平均年龄为 40.12±7.96 岁，对照组的平均年龄为 37.81±7.26 岁。两组在年龄或性别方面无统计学差异（P=0.229，P=0.740）。CSCR 组的血浆多巴胺水平为 29.85±9.39pg/ml，对照组为 23.93±7.33pg/ml（P=0.001）。CSCR 组的血浆肾上腺素水平为 60.73±25.69pg/ml，对照组为 45.77±18.55pg/ml（P=0.021）。CSCR 组的血浆去甲肾上腺素水平为 206.68±71.51pg/ml，对照组为 149.33±49.69pg/ml（P=0.001）。CSCR 组的血浆多巴胺、肾上腺素和去甲肾上腺素水平均显著升高。
我们认为多巴胺可能通过其受体和增强交感神经活性而成为 CSCR 发病机制中的一个可能因素。
