University of Basel, Basel, Switzerland.
University of Basel, Basel, Switzerland.
Mol Immunol. 2021 Feb;130:148-153. doi: 10.1016/j.molimm.2020.12.016. Epub 2020 Dec 25.
MR1 is an MHC class I-like molecule with unique structural and biological features that make it an important member among the molecules involved in antigen presentation to T cells. Distinctive features include ubiquitous expression of the MR1 gene and its monomorphism. Another relevant property is that the MR1 protein appears at very low levels on the plasma membrane and its surface expression is regulated by antigen binding. Finally, the nature of presented antigens differs from those that bind other presenting molecules and includes small metabolites of microbial and self-origin, small drugs and tumor-associated antigens. This opinion paper describes in detail some of those features and discusses recent literature in the field.
MR1 是一种 MHC Ⅰ类样分子，具有独特的结构和生物学特征，使其成为参与 T 细胞抗原呈递的分子中的重要成员。独特的特征包括 MR1 基因的广泛表达及其单态性。另一个相关特性是，MR1 蛋白在质膜上的表达水平非常低，其表面表达受抗原结合的调节。最后，呈递的抗原的性质与那些结合其他呈递分子的抗原不同，包括微生物和自身来源的小代谢物、小分子药物和肿瘤相关抗原。本观点文章详细描述了其中的一些特征，并讨论了该领域的最新文献。
