Université de Paris, Institut Cochin, INSERM U1016, CNRS UMR 8104, Paris, France.
Mol Immunol. 2021 Feb;130:142-147. doi: 10.1016/j.molimm.2020.12.014. Epub 2020 Dec 25.
MAIT cells are innate-like T cells that are enriched in mucosal sites and tissues including adipose tissue and liver. They play an important role in immunity against microbial pathogens. Recently, it has been reported that MAIT cells could also be important in metabolic diseases and can be involved in setting up and maintaining chronic inflammation. In this review, we give an overview of recent advances in understanding MAIT cells role in the ethology of this diseases.
MAIT 细胞是先天样 T 细胞，在包括脂肪组织和肝脏在内的黏膜部位和组织中丰富存在。它们在抵御微生物病原体的免疫中发挥重要作用。最近，据报道 MAIT 细胞在代谢疾病中也很重要，并可能参与慢性炎症的发生和维持。在这篇综述中，我们概述了近年来对 MAIT 细胞在这些疾病发病机制中作用的理解的进展。
