Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation (OMRF), Oklahoma City, OK, USA.
Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center (OUHSC), Oklahoma City, OK, USA.
Adv Exp Med Biol. 2022;1365:149-160. doi: 10.1007/978-981-16-8387-9_10.
Although we mostly think of αβ T cells as components of the adaptive immune system, a number of them differentiate into alternative lineages. These lineages express TCRs with limited diversity, and functionally bridge the gap between innate and adaptive immunity. They tend to be tissue resident, and mount potent cytokine responses very rapidly after activation, and their development and functional maturation are strongly influenced by the microbiome. Here, we compare the development pathways and interactions with the microbiome of natural killer T (NKT) cells and mucosal-associated invariant T (MAIT cells), the two best studied "innate-like" αβ T cell populations.
虽然我们通常认为αβ T 细胞是适应性免疫系统的组成部分，但其中一些细胞分化为不同的谱系。这些谱系表达具有有限多样性的 TCR，在先天免疫和适应性免疫之间起到桥梁作用。它们通常是组织驻留细胞，在激活后能迅速产生强烈的细胞因子反应，其发育和功能成熟受到微生物组的强烈影响。在这里，我们比较了自然杀伤 T（NKT）细胞和黏膜相关不变 T（MAIT）细胞这两种研究最多的“先天样”αβ T 细胞群体的发育途径和与微生物组的相互作用。
