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相当比例的加拿大过敏学家提供口服免疫治疗,但仍存在障碍。

A High Proportion of Canadian Allergists Offer Oral Immunotherapy but Barriers Remain.

机构信息

Department of Pediatrics, McMaster University, Hamilton, ON, Canada.

Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada.

出版信息

J Allergy Clin Immunol Pract. 2021 May;9(5):1902-1908. doi: 10.1016/j.jaip.2020.12.025. Epub 2020 Dec 29.

Abstract

BACKGROUND

Limited data on clinical implementation of oral immunotherapy (OIT) have been reported with incomplete evaluation of barriers.

OBJECTIVE

To survey Canadian allergists on their current practice of OIT and barriers to implementation and expansion of OIT.

METHODS

A survey investigating current practice and logistical and clinical barriers to offering or expanding OIT was distributed to all Canadian Society of Allergy and Clinical Immunology allergists.

RESULTS

Of 90 responding allergists, 52.2% reported offering OIT, most commonly to peanut. Food sublingual immunotherapy was offered by 7% of allergists. Having received training for OIT was associated with currently performing OIT (P = .008); 44.7% of allergists offering OIT had received training on OIT, and 81.4% not offering OIT had no training. A total of 87% of allergists performing OIT reported lack of efficacy data and lack of support staff and clinic space, and concerns about increased oral challenges (84%) were "moderately" to "extremely" important barriers to expanding OIT. For clinicians not offering OIT, concerns about safety (95%), after-hours support (95%), efficacy (93%), medicolegal risk (93%), and long-term practice implications (93%) were prioritized as significant barriers. Qualitative assessment suggested concerns about the practical challenges associated with OIT, the need for increased safety and efficacy data, and a desire for OIT guidelines and training.

CONCLUSION

The implementation of OIT faces many barriers, both clinical and logistical. Increasing high-quality safety and efficacy data may support those hesitant to offer OIT, and improving funding may address the practical infrastructure challenges. In addition, training will help expand access for allergists interested in performing OIT.

摘要

背景

目前已有有限的关于口服免疫疗法(OIT)临床应用的数据报告,但对实施 OIT 的障碍评估并不完整。

目的

调查加拿大过敏学家对 OIT 的当前实践及其实施和扩大 OIT 的障碍的看法。

方法

向所有加拿大过敏与临床免疫学协会的过敏学家分发了一项调查,内容为目前的实践情况,以及提供或扩大 OIT 的后勤和临床障碍。

结果

在 90 名回应的过敏学家中,52.2%报告提供 OIT,最常见的是花生。7%的过敏学家提供食物舌下免疫疗法。接受过 OIT 培训与目前进行 OIT 相关(P =.008);提供 OIT 的过敏学家中,44.7%接受过 OIT 培训,而未提供 OIT 的过敏学家中,81.4%未接受过培训。87%进行 OIT 的过敏学家报告缺乏疗效数据以及缺乏支持人员和诊所空间,并且对增加口服挑战的担忧(84%)是扩大 OIT 的“中度”到“极度”重要障碍。对于不提供 OIT 的临床医生,对安全性(95%)、下班后支持(95%)、疗效(93%)、医疗法律风险(93%)和长期实践影响(93%)的担忧被视为重大障碍。定性评估表明,人们对 OIT 相关的实际挑战、对增加安全性和疗效数据的需求以及对 OIT 指南和培训的渴望表示关注。

结论

OIT 的实施面临着许多临床和后勤方面的障碍。增加高质量的安全性和疗效数据可能会支持那些对提供 OIT 犹豫不决的人,而增加资金可能会解决实际的基础设施挑战。此外,培训将有助于扩大有兴趣进行 OIT 的过敏学家的服务范围。

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