Shi Yingying, Zhang Qinqin, Zhou Hao, Wang Liang, Chu Zhongdi, Jiang Xiaoshuang, Shen Mengxi, Thulliez Marie, Lyu Cancan, Feuer William, de Sisternes Luis, Durbin Mary K, Gregori Giovanni, Wang Ruikang K, Rosenfeld Philip J
Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA.
Department of Bioengineering, University of Washington, Seattle, Washington, USA.
Am J Ophthalmol. 2021 Apr;224:321-331. doi: 10.1016/j.ajo.2020.12.015. Epub 2020 Dec 24.
Correlations among enlargement rates (ERs) of geographic atrophy (GA) and choriocapillaris (CC) flow deficits (FDs), mean choroidal thickness (MCT), and choroidal vascularity index (CVI) were investigated using swept source-optical coherence tomography (SS-OCT) in age-related macular degeneration (AMD).
A retrospective review of prospective, observational case series.
Eyes with GA from AMD were imaged with SS-OCT using 6 × 6-mm scan pattern. GA lesions were identified and measured using customized en face structural images, and annual square root ERs of GA were calculated. At baseline, choriocapillaris FDs from different regions outside the GA were measured, and MCT and CVI from the entire scan area were measured. All measurements were performed using previously published and validated algorithms.
A total of 38 eyes from 27 patients were included. The CC FDs within each region around GA lesions were highly correlated with ERs of GA (all P < .005). CVI inside the GA region was correlated with the ERs (P = .03), whereas other choroidal measurements had no significant correlation with the ERs of GA (P > .06).
Statistically significant correlations were found between the ERs of GA and CC percentage of FD (FD%) from the entire scan region outside the GA and not just the region immediately adjacent to the GA. These results suggest that abnormal CC perfusion throughout the macula contributes to disease progression in eyes with GA. CVI inside the GA region could also be a potential indicator for the growth of GA.
使用扫频源光学相干断层扫描（SS-OCT）研究年龄相关性黄斑变性（AMD）中地理萎缩（GA）的扩大率（ERs）与脉络膜毛细血管（CC）血流缺损（FDs）、平均脉络膜厚度（MCT）和脉络膜血管指数（CVI）之间的相关性。
对前瞻性观察性病例系列进行回顾性研究。
对患有AMD且有GA的眼睛使用6×6毫米扫描模式进行SS-OCT成像。使用定制的表面结构图像识别并测量GA病变，并计算GA的年平方根ERs。在基线时，测量GA以外不同区域的脉络膜毛细血管FDs，以及整个扫描区域的MCT和CVI。所有测量均使用先前发表并经过验证的算法进行。
共纳入27例患者的38只眼睛。GA病变周围每个区域内的CC FDs与GA的ERs高度相关（所有P <.005）。GA区域内的CVI与ERs相关（P =.03），而其他脉络膜测量值与GA的ERs无显著相关性（P >.06）。
在GA的ERs与GA以外整个扫描区域而非仅紧邻GA区域的CC血流缺损百分比（FD%）之间发现了具有统计学意义的相关性。这些结果表明，整个黄斑区的CC灌注异常有助于GA患者眼睛的疾病进展。GA区域内的CVI也可能是GA进展的一个潜在指标。
