Research Center, Institut Universitaire de Gériatrie de Montréal. 4565 Queen Mary Rd, Montreal, QC H3W 1W5, Canada; Department of Psychology, Université de Montréal, Pavillon Marie-Victorin, 90 Vincent d'Indy, Montreal, QC H2V 2S9, Canada.
Research Center, Institut Universitaire de Gériatrie de Montréal. 4565 Queen Mary Rd, Montreal, QC H3W 1W5, Canada.
Neuroimage Clin. 2021;29:102526. doi: 10.1016/j.nicl.2020.102526. Epub 2020 Dec 7.
Cognitive reserve can be defined as a property of the brain that enables an individual to sustain cognitive performance in spite of age-related neural changes. This study uses brain imaging to identify which cognitive reserve mechanisms protect against the detrimental effect of hippocampal atrophy on associative memory.
The study included 108 older adults from the Quebec Consortium for the early identification of Alzheimer's disease. They received a magnetic resonance imaging examination to measure memory-related activations and hippocampal volume. Participants also completed a reserve-proxy questionnaire, and received a comprehensive clinical assessment.
Higher scores on the reserve questionnaire were associated with more activation in the right inferior temporal and left occipital fusiform gyri. The activation of the right temporal gyrus moderated the relationship between the volume of the hippocampus and face-name memory. A smaller volume was associated with weaker memory in participants with lower activation, but not in those with greater activation.
Recruitment of the temporal lobe protects against the detrimental effect of hippocampal atrophy on associative memory and contributes to cognitive reserve.
认知储备可以被定义为大脑的一种特性，它使个体能够在与年龄相关的神经变化的情况下保持认知表现。本研究使用脑成像来确定哪些认知储备机制可以抵御海马体萎缩对联想记忆的不利影响。
该研究纳入了来自魁北克早发性阿尔茨海默病联合会的 108 名老年人。他们接受了磁共振成像检查，以测量与记忆相关的激活和海马体体积。参与者还完成了储备代理问卷，并接受了全面的临床评估。
储备问卷的得分越高，右侧颞下回和左侧枕叶梭状回的激活程度越高。颞叶右回的激活调节了海马体体积与面孔-名字记忆之间的关系。体积较小与激活程度较低的参与者记忆较弱相关，但与激活程度较高的参与者无关。
颞叶的募集可以防止海马体萎缩对联想记忆的不利影响，并有助于认知储备。
