Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, 100029, China.
Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, 100029, China; Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden; BioInnovation Institute, Ole Maaløes Vej 3, DK2200 Copenhagen N, Denmark.
Curr Opin Biotechnol. 2021 Feb;67:26-34. doi: 10.1016/j.copbio.2020.11.009. Epub 2020 Dec 21.
Biosynthesis of oleochemicals enables sustainable production of natural and unnatural alternatives from renewable feedstocks. Yeast cell factories have been extensively studied and engineered to produce a variety of oleochemicals, focusing on both central carbon metabolism and lipid metabolism. Here, we review recent progress towards oleochemical synthesis in yeast based biorefineries, as well as utilization of alternative renewable feedstocks, such as xylose and l-arabinose. We also review recent studies of C1 compound utilization or co-utilization and discuss how these studies can lead to third generation yeast based biorefineries for oleochemical production.
油脂化学品的生物合成能够使天然和非天然替代品从可再生原料中可持续生产。酵母细胞工厂已被广泛研究和工程化，以生产各种油脂化学品，重点是中心碳代谢和脂代谢。在这里，我们回顾了基于酵母的生物炼制厂中油脂化学品合成的最新进展，以及替代可再生原料（如木糖和 L-阿拉伯糖）的利用。我们还回顾了最近关于 C1 化合物利用或共利用的研究，并讨论了这些研究如何导致第三代基于酵母的生物炼制厂用于油脂化学品生产。
